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Table 1 Relationship between fascin and MMP-9 expressions and clinicopathological parameters of the studied breast carcinomas (n = 67)

From: Association of Fascin and matrix metalloproteinase-9 expression with poor prognostic parameters in breast carcinoma of Egyptian women

  Fascin expression MMP-9 expression
Variable n (%) Negative n = 38 Positive n = 29 P value Negative n = 33 Positive n = 33 P value
Age (years)        
≤ 50 22 (33) 10 (45.5%) 12 (54.5%) 0.193* 10 (45.5%) 12 (54.5%) 0.664*
>50 45 (67) 28 (62.2%) 17 (37.8%) (NS) 23 (51.1%) 22 (48.9%) (NS)
Tumor size (cm)        
≤5 41 (61.19) 27 (65.9%) 14 (34.1%) 0.058* 24 (58.5%) 17 (41.5%) 0.056*
>5 26 (38.81) 11 (42.3%) 15 (57.7%) (NS) 9 (34.6%) 17 (65.4%) (NS)
Grades        
I 7 (10.4) 3 (42.9%) 4 (57.1%) 0.111** 2 (28.6%) 5 (71.4%) 0.088**
II 44 (65.7) 29 (65.9%) 15 (34.1%) (NS) 26 (59.1%) 18 (40.9%) (NS)
III 16 (23.9) 6 (37.5%) 10 (62.5%)   5 (31.2%) 11 (68.8%)  
Lymph nodal status        
Node – 24 (35.8) 20 (83.3%) 4 (16.7%) 0.001* 18 (75.0%) 6 (25.0%) 0.002*
Node + 43 (64.2) 18 (41.9%) 25 (58.1%) (S) 15 (34.9%) 28 (65.1%) (S)
Stage        
I 18 (26.87) 15 (83.3%) 3 (16.7%) 0.004* 14 (77.8%) 4 (22.2%) 0.005*
II 29 (43.28) 17 (58.6%) 12 (41.4%) (S) 14 (48.3%) 15 (51.7%) (S)
III 20 (29.85) 6 (30.0%) 14 (70.0%)   5 (25.0%) 15 (75.0%)  
Estrogen receptor        
Negative 21 (31.3) 6 (28.6%) 15 (71.4%) 0.002* 5 (23.8%) 16 (76.2%) 0.005*
Positive 46 (68.7) 32 (69.6%) 14 (30.4%) (S) 28 (60.9%) 18 (39.1%) (S)
Progesterone receptor        
Negative 24 (35.8) 7 (29.2%) 17 (70.8%) 0.001* 6 (25.0%) 18 (75.0%) 0.003*
Positive 43 (64.2) 31 (72.1%) 12 (27.9%) (S) 27 (62.8%) 16 (37.2%) (S)
HER2        
Negative 55 (82.1) 33 (60.0%) 22 (40.0%) 0.246* 30 (54.5%) 25 (45.5%) 0.064*
Positive 12 (17.9) 5 (41.7%) 7 (58.3%) (NS) 3 (25.0%) 9 (75.0%) (NS)
  1. *Chi-square test.
  2. **Fisher exact test.
  3. S: significant.
  4. NS: non-significant.
  5. n = number of cases.