Figure 4

Light chain restriction in B cell lymphomas. A-B: CLL/SLL (A) residual germinal center on left with sheets of monoclonal KAPPA light chain restricted lymphoma cells on the right (100×); (B) higher power view of KAPPA light chain restricted cells (500×). C-E: DLBCL (C) diffuse sheets of LAMBDA light chain restricted cells (100×); (D) same case showing intermediate magnification of LAMBDA light chain restricted lymphoma cells (400×); (E) same case showing higher power view with centroblastic morphology and LAMBDA light chain restriction. Rather than an inherent difference in the chromogens, but rather due to the larger cell size and lower nuclear to cytoplasmic ratios in DLBCL as compared to SLL or FL, the cellular detail is easier to appreciate in E than in images B or H (600×). F-H: Follicular lymphoma (F) low power view showing neoplastic germinal centers with KAPPA light chain restriction and cuff of polyclonal plasma cells (100×); (G) same case at intermediate power showing KAPPA light chain restricted FL; (H) same case at higher power showing KAPPA light chain restriction of both small and large neoplastic cells (600×).