Table 1 General characteristics of colorectal cancer (CRC) patients and controls
From: Association between miR-27a genetic variants and susceptibility to colorectal cancer
Variable s | Cases | Percentage (%) | Control | Pecentage (%) | P value | OR (95% CI) |
|---|---|---|---|---|---|---|
Age (years, mean ± SD) | 54.9 ± 11.2 | 55.4 ± 10.1 | 0.15 | |||
Sex | ||||||
Male | 103 | 50.24 | 225 | 49.45 | 1 (Ref) | |
Female | 102 | 49.76 | 230 | 50.55 | 0.859 | 1.032 (0.742 - 1.435) |
Smoking status | ||||||
No | 61 | 29.76 | 201 | 44.18 | 1 (Ref) | |
Yes | 144 | 70.24 | 254 | 55.82 | < 0.001 | 1.868 (1.314 - 2.656) |
Smoking amount (pack-years) | ||||||
0 | 61 | 29.76 | 201 | 44.18 | 1 1 (Ref) | |
< 1500 | 51 | 24.87 | 123 | 27.03 | 0.453 | 1.21 (0.88 – 2.11) |
> 1500 | 93 | 45.36 | 131 | 28.79 | < 0.001 | 2.34 (1.58 -3.46) |
Smoking duration (years) | ||||||
0 | 61 | 29.76 | 201 | 44.18 | (Ref) 1 | |
< 5 | 12 | 5.85 | 37 | 8.13 | 0.325 | 1.069 (0.525 – 2.177) |
5 - 10 | 39 | 19.02 | 81 | 17.80 | 0.067 | 1.587 (0.984 – 2.558) |
> 10 | 93 | 45.36 | 150 | 32.97 | 0.002 | 2.43 (1.389 – 3.005) |
Alcohol | ||||||
No | 89 | 43.41 | 236 | 51.87 | 1 (Ref) | |
Yes | 116 | 56.59 | 219 | 48.13 | 0.044 | 1.405 (1.008 - 1.957) |
Alcohol amount (cups/day) | ||||||
0 | 89 | 43.41 | 236 | 51.87 | 1 (Ref) | |
1 – 3 | 39 | 19.02 | 102 | 22.42 | 0.284 | 1.014 (0.651 – 1.578)– |
> 3 | 77 | 38.54 | 117 | 26.71 | 0.012 | 1.790 (1.230 – 2.606) |
Alcohol use duration | ||||||
0 | 89 | 43.41 | 236 | 51.87 | 1 (Ref) | |
< 5 | 32 | 15.61 | 78 | 17.53 | 0.329 | 1.088 (0.674 – 1.755) |
5 - 10 | 29 | 14.15 | 65 | 14.61 | 0.436 | 1.183 (0.717 – 1.953) |
> 10 | 55 | 26.83 | 76 | 17.08 | < 0.001 | 1.919 (1.256 – 2.933) |
Fruit intake (times/week) | ||||||
≤ 1 | 68 | 33.17 | 120 | 26.97 | 1 (Ref) | |
2-4 | 53 | 25.85 | 165 | 37.07 | 0.042 | 0.588 (0.380 – 0.899) |
≥ 5 | 84 | 40.98 | 170 | 38.20 | 0.245 | 0.872 (0.587 – 1.296) |
Vegetable intake (times/week) | ||||||
≤ 1 | 85 | 41.46 | 116 | 26.07 | 1 (Ref) | |
2-4 | 75 | 36.59 | 131 | 29.43 | 0.546 | 0.781 (0.524 – 1.164) |
≥ 5 | 45 | 21.95 | 198 | 44.49 | < 0.001 | 0.310 (0.202 – 0.476) |
Education status | ||||||
High school or less | 109 | 228 | 1 (Ref) | |||
College or University | 81 | 202 | 0.839 (0.594 – 1.183) | |||
Master or more | 15 | 15 | 2.092 (0.987 – 4.434) | |||
Income (RMB/year) | ||||||
≤ 100,000 | 98 | 47.80 | 109 | 24.49 | 1 (Ref) | |
100,000 – 300,000 | 88 | 42.93 | 252 | 56.12 | 0.001 | 0.388 (0.270 – 0.560) |
≥300,000 | 19 | 9.27 | 84 | 18.88 | < 0.001 | 0.252 (0.143 – 0.444) |