Figure 3

Transmission electron micrographs of patient 1 (A-E) and patient 2 (F). A. Classic adenoma cells on the left. The cells on the right contained dense inclusions (2,000x). B. Some of the cells had multiple inclusions with variable electron density (6,000x). C. This election dense inclusion may represent a degenerated mitochondrion containing possible remnant cristae as it is surrounded by a membrane. However, most of the dense inclusions had no lining membrane (60,000x). D. Inclusions with characteristic concentrically laminated membranes similar to those surrounding typical spironolactone bodies, but without an electron dense core (12,000x). E. Some cells contained inclusions similar to typical spironolactone bodies, complete with an electron dense core surrounded by concentrically laminated membranes (40,000x). F. In patient 2, using paraffin-embedded tissue, only scroll-like inclusions without electron dense cores were identified (60,000x).