Association of XPD Lys751Gln polymorphism with head and neck cancer susceptibility: evidence from 11,443 subjects

Diagnostic Pathology

Table 1 Characteristics of included studies

Author	Year	Country	Ethnicity	Source	Genotyping method	Cancer type	Total number		Cases			Controls			HWE of controls
Author	Year	Country	Ethnicity	Source	Genotyping method	Cancer type	Cases	Controls	Lys/Lys	Lys/Gln	Gln/Gln	Lys/Lys	Lys/Gln	Gln/Gln
Sturgis [26]	2000	America	Caucasian	HB	PCR-RFLP	SCCHN	189	496	75	83	31	218	221	57	0.9304
Gajecka [21]	2005	Poland	Caucasian	HB	PCR-RFLP	LC	293	320	110	135	48	87	175	58	0.0659
Huang [23]	2005	America	Caucasian	Mix*	TaqMan-PCR	HNC	425	683	176	188	61	296	292	95	0.0951
Rydzanicz [24]	2005	Poland	Caucasian	HB	PCR-RFLP	HNC	172	143	69	73	30	54	64	25	0.4265
Kietthubthew [32]	2006	Thailand	Asian	PB	PCR-RFLP	SCCOC	105	164	83	21	1	126	36	2	0.7489
Matullo [25]	2006	Europe	Caucasian	nest	TaqMan-PCR	UADC	82	1094	34	39	9	397	504	193	0.1330
Ramachandran [37]	2006	India	Asian	HB	PCR-RFLP	OC	110	110	49	46	15	71	31	8	0.0908
An [22]	2007	America	Caucasian	HB	PCR-RFLP	SCCHN	829	854	330	394	105	358	386	110	0.7091
Bau [27]	2007	Taiwan	Asian	HB	PCR-RFLP	OC	154	105	134	18	2	89	15	1	0.6824
Yang [29]	2007	China	Asian	PB	PCR-RFLP	NPC	153	168	128	24	1	124	43	1	0.1805
Majumder [31]	2007	India	Asian	HB	PCR-RFLP	OC	309	388	158	125	26	190	158	40	0.4030
Harth [35]	2008	Germany	Caucasian	HB	PCR-RFLP	SCCHN	312	300	111	154	47	108	149	43	0.4642
Mitra [34]	2009	North India	Caucasian	HB	PCR-RFLP	SCCHN	275	385	88	148	39	163	179	43	0.5571
Jelonek [33]	2010	Poland	Caucasian	HB	PCR-RFLP	HNC	103	110	29	52	22	38	60	12	0.1030
Ji [28]	2010	Korea	Asian	HB	PCR-SBE	SCCHN	267	348	232	32	3	298	48	2	0.9645
Stembalska [38]	2011	Poland	Caucasian	HB	PCR-RFLP	LSCC	60	100	20	26	14	32	46	22	0.4795
Kumar [36]	2012	North India	Caucasian	HB	PCR-RFLP	SCCHN	278	278	92	125	61	129	110	39	0.0531
Yuan [30]	2012	China	Asian	PB	TaqMan-PCR	HNC	394	887	333	57	4	752	129	6	0.8556

HB hospital-based study, PB population-based study, *two population-based studies and one hospital-based study, nest nested case–control study, PCR-RFLP polymerase chain reaction-restriction fragment length polymorphism, PCR-SBE polymerase chain reaction-single base extension, HNC head and neck cancer, SCCHN squamous cell cancer of the head and neck, NPC nasopharyngeal cancer, LC laryngeal cancer, LSCC laryngeal squamous cell cancer, UADC upper aerodigestive tract cancer, OC oral cance, HWE Hardy–Weinberg equilibrium.

ISSN: 1746-1596