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Table 2 Review from the literature of 61 reported patients with oligodendroglioma with metastases outside the CNS

From: Occipital anaplastic oligodendroglioma with multiple organ metastases after a short clinical course: a case report and literature review

Patient no.

Gender

Subjects

WHO grade

Age at diagnosis (y)

Location of metastasis

OS (months)

Time between presentation of primary tumor and metastasis (months)

Molecular biomarkers tested

Reference

1

F

British

ODG, low grade early, later *AO

25

Cervical lymph nodes, scalp, lung, bone

84

*

*

James et al. 1951 [26]

2

F

American

ODG, *grade

7

Scalp, bone, soft tissue, liver

36

*

*

Spataro et al. 1968 [27]

3

F

Austrian

ODG, *grade

58

Bone

30

*

*

Jellinger et al. 1969 [28], (also reported as Schuster et al. 1976 [29])

4

M

American

*ODG, *grade

45

Bone marrow

17

*

*

Smith et al. 1969 [2]

5

*

*

ODG, initially low grade

3.5

Lymph nodes, lungs, adrenal

21

*

*

Kernohan 1971 [30]

6

F

Scottish

Malignant glioma, some ODG features

21

Bone

9

*

*

Eade et al. 1971 [31]

7

M

Scottish

Small cell GBM with regions of ODG

23

Bone

12

*

*

 

8

M

French

*ODG, *grade

57

Lymph nodes, bone

20

*

*

Cappellaere et al. 1972 [32]

9

M

French

*ODG, *grade

22

Lymph nodes, bone, parotid gland

25

*

*

 

10

F

British

Malignant glioma, some ODG features

30

Pleura

156

*

*

Brander et al. 1975 [33]

11

M

German

*ODG, *grade

40

Bone, lymph nodes, lungs

86

*

*

Kummer et al. 1977 [34]

12

*

Canadian

*ODG, *grade

*

Scalp

*

*

*

Chin et al. 1980 [35]

13

F

American

ODG, grade II

33

Bone, lymph nodes, scalp, soft tissue

50

*

*

Ordonez et al. 1981 [36]

14

M

Japanese

Grade III

32

Bone

76

14

*

Nakamura et al. 1985 [37]

15

M

*

ODG, malignant

41

Bone marrow

48

*

*

Newman et al. 1985 [38]

16

*

Canadian

ODG, *grade, some astro

12

Bone, lymph nodes, scalp

104

*

*

Macdonald et al. 1989 [39]

17

*

Canadian

ODG, *grade

44

Cervical lymph nodes, bone,

48

*

*

 

18

F

Canadian

ODG, grade III

36

Bone, lymph nodes

60

*

*

 

19

*

Canadian

ODG, *grade, some astro

32

Bone, lymph nodes, scalp

38

*

*

 

20

*

Canadian

ODG, *grade

34

Bone

76+

*

*

 

21

M

Canadian

ODG, grade III

27

Bone

37

*

*

 

22

*

Canadian

ODG, *grade, some astro

47

Bone

26+

*

*

 

23

*

Polish

Grade III

*

*

*

*

*

Rolski et al. 1993 [40]

24

*

German

*

*

Cervical lymph nodes

*

*

*

Steininger et al. 1993 [41]

25

M

British

ODG, grade III

54

Bone marrow

12

*

*

Gerrard et al. 1995 [42]

26

*

German

Grade III

*

Cervical lymph nodes

*

48

*

Schroder et al. 1995 [43]

27

M

Italian

ODG, grade II

58

Chest wall, bone marrow, possibly liver

48

*

*

Monzani et al. 1996 [44]

28

M

British

ODG, grade III

43

Bone marrow, liver

3

*

*

Dawson 1997 [45]

29

M

Austrian

ODG-astrocytoma grade III

62

Thoracic wall, pleura, bone marrow

288

6

*

Finsterer et al. 1998 [46]

30

M

Indian

Grade III

50

Bone and bone marrow

7+

*

*

Anand et al. 2001 [47]

31

*

Italian

ODG, grade II

25

Bone

84+

*

*

Giordana et al. 2002 [48]

32

M

Indian

Grade III

50

Bone marrow

17

*

*

Sharma et al. 2003 [49]

33

M

American

Grade III

33

Bone marrow

38+

*

*

Choon et al. 2004 [50]

34

M

Canadian

Grade III

35

Bone

84

23

Allelic LOH of chromosome 1p (1p-), a rise in serum alkaline phosphatase

Morrison et al. 2004 [51]

35

F

American

ODG, grade II early, later AO, grade III

41

Parotid gland

79+

68

Codeletion of 1p/19q

Wang et al. 2004 [52]

36

M

American

ODG, low grade early, later AO, grade III

28

Bone marrow

120

5

Positive for S-100 marker with immunohistochemical stain

Al-Ali et al. 2005 [23]

37

M

American

Atypical meningioma, early, later AO, grade III

32

Bone, bone marrow, cervical and thoracic lesions

168

27

Elevated serum lactate dehydrogenase and alkaline phosphatase, positive for S-100, and GFAP with immunohistochemical stain

Merrell et al. 2006 [53]

38

F

American

AO, grade III

71

Bone, bone marrow,

17

13

Codeletion of 1p/19q, positive for S-100, and GFAP with immunohistochemical stain, elevated serum hemoglobin level

 

39

F

Chinese

ODG, *grade

64

Pleura, bone

*

84

Positive for S-100, Olig2 and GFAP with immunohistochemical stain

Lee et al. 2006 [54]

40

M

American

ODG, grade II early, later AO, grade III

15

Pleura, bone, lungs, adrenal gland, chest, liver, abdomen

62

31

Codeletion of 1p/19q

Bruggers et al. 2007 [55]

41

F

Japanese

AO, grade III

17

Spleen, liver, pancreas, bone, spinal dura mater, dorsal root ganglia, lungs, lymph nodes, iliopsoas muscle

144

3

Markedly positive for Ki-67, and positive for Olig2 with immunohistochemical stain,

Uzuka et al. 2007 [56]

42

F

Korean

AO, grade III

48

Liver, lungs

28

27

Not presented

Han et al. 2008 [4]

43

M

Italian

AO, grade III

40

Bone, bone marrow, liver

10

5

Not presented

Zustovich et al. 2008 [57]

44

F

Slovenian

AO, grade III

54

Cervical and neck lymph nodes

48

12

Positive for S-100, and GFAP with immunohistochemical stain

Volavsek et al. 2009 [58]

45

F

Slovenian

AOA, grade III

30

Bone

58+

17

Positive for GFAP with immunohistochemical stain

 

46

M

Japanese

AO, grade III

53

Lymph nodes, bone, spinal dura mater, thymus gland, chest wall

30

24

Codeletion of 1p/19q

Noshita N, et al. 2010 [59]

47

F

Japanese

AO, grade III

73

Cervical lesion

18+

18

*

Oshiro S, et al. 2010 [60]

48

M

Dutch

AO, grade III

59

Bone marrow

33

31

Codeletion of 1p/19q, positive for S-100, and p53 with immunohistochemical stain

Krijnen JL, et al. 2010 [61]

49

M

Dutch

*ODG, *grade

24

Bone marrow

*

84

Not presented

 

50

M

Dutch

AO, grade III

34

Cervical lymph nodes, iliopsoas muscle

*

not presented

Not presented

 

51

M

Dutch

AO, grade III

64

Axillary lymph nodes

*

34

Not presented

 

52

M

Dutch

AO, grade III

72

Bone marrow

*

6

Not presented

 

53

F

Dutch

*ODG, *grade

67

Bone marrow

*

29

Not presented

 

54

M

Dutch

AO, grade III

62

Retroperitoneal lymph nodes

*

21

Not presented

 

55

M

Turkish

AO, grade III

55

Bone marrow

23+

11

Positive for GFAP with immunohistochemical stain

Kural C, et al. 2011 [62]

56

M

Chinese

AO, grade III

37

Bone

58+

37

Positive for S-100, and GFAP with immunohistochemical stain

Wu Y, et al. 2011 [63]

57

M

Italian

AO, grade III

40

Bone marrow

61

57

Positive for enolase, and GFAP with immunohistochemical stain

Cordiano V, et al. 2012 [64]

58

F

Turkish

ODG, *grade

*

Cervical lymphatic chain

*

60

Codeletion of 1p/19q

Can B, et al. 2012 [65]

59

M

Turkish

AO, grade III

58

Breast

*

*

*

Alacacioglu A, et al. 2012 [66]

60

M

Irish

AO, grade III

58

Bone

120+

108

Codeletion of 1p/19q, positive for GFAP with immunohistochemical stain

Greene J, et al. 2013 [67]

61

M

Chinese

AO, grade III

45

Bone, bone marrow, lymph nodes

16

13

No deletion of 1p/ 19q, PTEN mutation in exon 2, MGMT promoter methylated, positive for IDH1, Ki-67, Olig2, and GFAP, negative for MGMT, EMA and Vim with immunohistochemical stain

Present case

  1. F: f emale, M: male, OS: overall survival, WHO: World Health Organization, LOH: loss of heterozygosity, ODG: oligodendroglioma, AO: anaplastic oligodendroglioma, AOA: anaplastic oligoastrocytoma, GBM: glioblastoma multiforme.
  2. *Not provided in the corresponding literature.
  3. + alive at publication.