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Table 2 Relationship between EGFR protein expression, EGFR copy number and clinicopathological characteristics of adrenocortical carcinomas

From: Adrenal cortical neoplasms: a study of clinicopathological features related to epidermal growth factor receptor gene status

  FISH positive (n = 11) FISH negative (n = 11) P-value IHC positive (n = 14) IHC negative (n = 8) P-value
Sex
Males 7 6 1.000* 8 5 1.000*
Females 4 5 6 3  
Age (yrs)
Mean 38.6 48.2 0.224 42.8 44.5 0.836
Range 2-61 20-75   2-75 17-72  
Tumor size (cm)
Mean 11.5 13.0 0.594 10.5 15.3 0.097
Range 3-24 4-24 3-24 7-24
Tumor weight (g)
Mean 761.8 932.1 0.730 579.9 1314.4 0.102
Range 12-2700 16-3250 12-3250 95-2700
Hormonal function
Functioning 5 3 0.659* 7 1 0.079*
Non-functioning 6 8 7 7
Recurrence or metastasis
Yes 5 6 0.670 6 5 0.659*
No 6 5 8 3
TNM stage
I 1 0 1.000* 1 0 1.000*
II-IV 10 11 13 8  
  1. EGFR, epidermal growth factor receptor; IHC, immunohistochemistry; FISH, fluorescence in situ hybridization.
  2. *Fisher’s exact test (two-tailed).