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Table 2 Relationship between EGFR protein expression, EGFR copy number and clinicopathological characteristics of adrenocortical carcinomas

From: Adrenal cortical neoplasms: a study of clinicopathological features related to epidermal growth factor receptor gene status

 

FISH positive (n = 11)

FISH negative (n = 11)

P-value

IHC positive (n = 14)

IHC negative (n = 8)

P-value

Sex

Males

7

6

1.000*

8

5

1.000*

Females

4

5

6

3

 

Age (yrs)

Mean

38.6

48.2

0.224

42.8

44.5

0.836

Range

2-61

20-75

 

2-75

17-72

 

Tumor size (cm)

Mean

11.5

13.0

0.594

10.5

15.3

0.097

Range

3-24

4-24

3-24

7-24

Tumor weight (g)

Mean

761.8

932.1

0.730

579.9

1314.4

0.102

Range

12-2700

16-3250

12-3250

95-2700

Hormonal function

Functioning

5

3

0.659*

7

1

0.079*

Non-functioning

6

8

7

7

Recurrence or metastasis

Yes

5

6

0.670

6

5

0.659*

No

6

5

8

3

TNM stage

I

1

0

1.000*

1

0

1.000*

II-IV

10

11

13

8

 
  1. EGFR, epidermal growth factor receptor; IHC, immunohistochemistry; FISH, fluorescence in situ hybridization.
  2. *Fisher’s exact test (two-tailed).