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Table 3 Copy number variations of mtDNA in laryngeal cancer — univariate associations with clinicopathological characteristics

From: Low copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in early-stage laryngeal cancer patients

Characteristics

Copy number <4.02

 

Copy number >5.42

 

OR* (95% CI)

P

OR* (95% CI)

P

Male vs. Female

2.73 (0.37-20.28)

0.33

1.89 (0.30-11.86)

0.50

Age

1.00 (0.96-1.05)

0.92

1.01 (0.97-1.05)

0.78

Differentiation1

1.02 (0.25-4.10)

0.98

0.64 (0.17-3.01)

0.64

Tumor invasion2

1.43 (0.92-2.25)

0.11

0.94 (0.60-1.46)

0.77

TNM stage3

1.53 (1.04-2.25)

0.03

1.04 (0.71-1.51)

0.84

LNM4

2.31 (0.90-5.95)

0.08

1.50 (0.58-3.89)

0.41

Smoking history5

0.46 (0.16-1.34)

0.16

0.29 (0.10-0.84)

0.02

Survival status6

0.81 (0.36-1.84)

0.61

0.79 (0.35-1.77)

0.56

  1. *OR: odds ratio with 95% confidence interval; 1Differentiation (well or moderate; poor or undifferentiation); 2Tumor invasion (T1; T2; T3; T4); 3TNM stage (I; II; III; IV); 4LNM (lymph node metastasis); 5Smoking history (at least 10 pack-years); 6Survival status (Alive vs. Dead); The cases with 4.02-5.42 mtDNA copies were used as reference.