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Table 7 Prognostic value of clinicopathological factors and copy number variation of mtDNA in univariate and multivariate Cox regression analysis (n =204)

From: Low copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in early-stage laryngeal cancer patients

 

Univariate analysis

Multivariate analysis

Variable

Hazard Ratio (95% CI)

P

Hazard Ratio (95% CI)

P

Copy number

    

 4.02 ~ 5.42

1.00 (reference)

 

1.00 (reference)

 

 <4.02

1.00 (0.54–1.83)

0.99

1.78 (0.93–3.42)

0.09

 >5.42

0.84 (0.53–1.34)

0.46

1.40 (0.84–2.35)

0.20

Lymph node metastasis

    

 No

1.00 (reference)

 

1.00 (reference)

 

 Yes

2.70 (1.71–4.25)

<0.001

2.43 (1.46–4.05)

0.001

Tumor invasion

    

 T1

1.00 (reference)

 

1.00 (reference)

 

 T2

1.98 (1.15–3.43)

0.015

1.71 (0.95–3.06)

0.07

 T3

2.32 (1.29–4.18)

0.005

2.24 (1.22–4.14)

0.01

 T4

5.46 (2.28–13.11)

<0.001

5.42 (2.08–14.13)

0.001

Differentiation

    

 Well/moderate

1.00 (reference)

 

1.00 (reference)

 

 Poor/undifferentiation

2.78 (1.10–7.07)

0.03

2.33 (0.88–6.15)

0.09