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Table 7 Prognostic value of clinicopathological factors and copy number variation of mtDNA in univariate and multivariate Cox regression analysis (n =204)

From: Low copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in early-stage laryngeal cancer patients

  Univariate analysis Multivariate analysis
Variable Hazard Ratio (95% CI) P Hazard Ratio (95% CI) P
Copy number     
 4.02 ~ 5.42 1.00 (reference)   1.00 (reference)  
 <4.02 1.00 (0.54–1.83) 0.99 1.78 (0.93–3.42) 0.09
 >5.42 0.84 (0.53–1.34) 0.46 1.40 (0.84–2.35) 0.20
Lymph node metastasis     
 No 1.00 (reference)   1.00 (reference)  
 Yes 2.70 (1.71–4.25) <0.001 2.43 (1.46–4.05) 0.001
Tumor invasion     
 T1 1.00 (reference)   1.00 (reference)  
 T2 1.98 (1.15–3.43) 0.015 1.71 (0.95–3.06) 0.07
 T3 2.32 (1.29–4.18) 0.005 2.24 (1.22–4.14) 0.01
 T4 5.46 (2.28–13.11) <0.001 5.42 (2.08–14.13) 0.001
Differentiation     
 Well/moderate 1.00 (reference)   1.00 (reference)  
 Poor/undifferentiation 2.78 (1.10–7.07) 0.03 2.33 (0.88–6.15) 0.09