Table 2 Overview of folds with capacity to bind sugars and of lectin classes
From: Introduction to glycopathology: the concept, the tools and the perspectives
Type of fold | Example for lectin | Example for ligand |
|---|---|---|
β-sandwich (jelly-roll) | a) galectins | β-galactosides |
b) calnexin, calreticulin | Glc1Man9GlcN Ac2 | |
c) ERGIC-53, VIP36, VIPL | ManxGlcN Ac2 | |
d) CRDa of Fbs1 in SCF E3 ubiquitin ligase and peptide-N-glycanase | Man3GlcN Ac2; mannopentaose | |
|  | e) pentraxins | glycosaminoglycans, MOβDG, 3-sulfated Gal, GalN Ac and GlcA, Man-6-phosphate |
| Â | f) G-domains of the LNS family (laminin, agrin) | heparin |
C-type | asialoglycoprotein receptor, collectins, selectins | Fuc, Gal, GalN Ac, Man, heparin tetrasaccharide |
I-type (Ig fold) | N-CAM, TIM-3, siglecs | Man6GlcN Ac2, HNK-1 epitope, α2,3/6-sialylated glycans |
P-type | mannose-6-phosphate receptors (MR) and proteins with MR homology domain (erlectin, OS-9) | Man-6-phosphate, Man5,8GlcN Ac2 |
β-trefoil | a) fibroblast growth factors | heparan sulfate |
b) cysteine-rich domain of C-type macrophage mannose receptor | GalN Ac-4-sulfate in LacdiN Ac | |
c) lectin domain in GalN Ac-Tsb involved in mucin-type O-glycosylation | GalN Ac | |
d) hemolytic lectin CEL-III of sea cucumber and lectin EW29 of earthworm | Gal | |
β-propeller | a) 4-bladed: tachylectin-3 | S-type lipopolysaccharide GlcN Ac/GalN Ac |
b) 5-bladed: tachylectin-2 | ||
c) 6-bladed: tachylectin-1 | KDO | |
β-prism I | secretory proteins zg16p/b | Man, heparan sulfate |
β-prism II | pufferfish (fugu) lectin | Man |
β-barrel with jelly-roll topology | tachylectin-4, eel (Anguilla anguilla) agglutinin, X-epilectin | Fuc |
Fibrinogen-like domain | a) ficolins | GlcN Ac |
b) intelectins (mammalian, Xenopus) | Galf, pentoses | |
c) tachylectin-5 | N-acetylated sugars sialic acid | |
d) slug (Limax flavus) lectin | ||
Link module | CD44, TSG-6, LYVE-1, aggregating proteoglycans | hyaluronic acid |
Hevein-like domain | Tachycytin and spider (Selenocosmia huwena) neurotoxin; cobra venom cardiotoxin | GalN Ac; heparin-derived disaccharide |
(β/α)8 barrel (glycoside hydrolase family 18) | YKL-40 (human cartilage glycoprotein-39; chitinase-like lectin) | (GlcN Ac)n |
Short consensus repeat (complement control protein module) | Factor H (complement regulator) | glycosaminoglycans, sialic acid |