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Table 4 Diagnostic values of combined detection of BRAF mutation and various DNA methylation markers on FNAB specimens for PTC detection [percent (PTCs with BRAF mutation or methylation-positive/total PTCs, sensitivity; benign nodules with BRAF mutation or methylation-negative/total benign nodules, specificity; PTCs with BRAF mutation or methylation-positive/total positive cases, PPV; benign nodules with BRAF mutation or methylation-negative/total negative nodules, NPV)]

From: Analysis of BRAFV600E mutation and DNA methylation improves the diagnostics of thyroid fine needle aspiration biopsies

  Cut-off values Training group (n =79)
Sensitivity (%) Specificity (%) PPV (%) NPV (%) Accuracy (%)
BRAF V600E N/A 71.43 (30/42) 100 (37/37) 100 (30/30) 75.51 (37/49) 71.43
CALCA + BRAF V600E 8.022 71.43 (30/42) 100 (37/37) 100 (30/30) 75.51 (37/49) 71.43
DAPK1 + BRAF V600E 0.64 78.57 (33/42) 100 (37/37) 100 (33/33) 80.43 (37/46) 78.57
TIMP3 + BRAF V600E 6.46 73.81 (31/42) 100 (37/37) 100 (31/31) 77.08 (37/48) 73.81
RAR-beta + BRAF V600E 11.21 73.81 (31/42) 100 (37/37) 100 (31/31) 77.08 (37/48) 73.81
RASSF1A + BRAF V600E 0.003 76.19 (32/42) 100 (37/37) 100 (32/32) 78.72 (37/47) 76.19
All five genes + BRAFV600E N/A 85.71 (36/42) 100 (37/37) 100 (36/36) 86.05 (37/43) 85.71
  Cut-off values Test group (n =38)
Sensitivity (%) Specificity (%) PPV (%) NPV (%) Accuracy (%)
BRAF V600E N/A 70.00 (14/20) 100 (18/18) 100 (14/14) 75.00 (18/24) 70.00
CALCA + BRAF V600E 8.022 75.00 (15/20) 100 (18/18) 100 (15/15) 78.26 (18/23) 75.00
DAPK1 + BRAF V600E 0.64 80.00 (16/20) 94.44 (17/18) 94.12 (16/17) 80.95 (17/21) 74.44
TIMP3 + BRAF V600E 6.46 75.00 (15/20) 100 (18/18) 100 (15/15) 78.26 (18/23) 75.00
RAR-beta + BRAF V600E 11.21 75.00 (15/20) 100 (18/18) 100 (15/15) 78.26 (18/23) 75.00
RASSF1A + BRAF V600E 0.003 75.00 (15/20) 100 (18/18) 100 (15/15) 78.26 (18/23) 75.00
All five genes + BRAFV600E N/A 85.00 (17/20) 94.44 (17/18) 94.44 (17/18) 85.00 (17/20) 79.44