Kaplan-Meier curves for different tumor types. The clinical course (overall survival) (OS) was dependant on the tumor type (AC vs. SCC vs. SCLC) (A), the extent of the tumor (pT) (B) as well as the extent of lymphonodular spread (pN) (C), indicating a representative tumor cohort in the present study. In SCC and SCLC specimens, moderate resp. strong hamartin expression survival was significantly poorer compared to cases with no expression or equivocal staining characteristics (p = 0.014 resp. p < 0.01) (E, F). This effect was not obtained for AC specimens (p > 0.05) (D). n: negative, e: equivocal, m: moderate, s: strong hamartin expression.