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Table 2 Staining of AC with established EGFR mutation status

From: Tuberous-sclerosis complex-related cell signaling in the pathogenesis of lung cancer

  EGFR sequence alterations Immunohistochemical analysis
No. EGFR mutation Mutation Exon TSC1 P-TSC2 P-mTOR
1 Yes c.2573 T > G; p.L858R 21 --- --- ---
2 Yes p.E746_P753 delinsIS c.2236_2259(24 bp)delinsATCTCG 19 + + +
3 Yes c.2236_2250del p.E746_A750del 19 --- --- ---
4 Yes p.L858R c.2573 T > G 21 --- --- +
5 Yes c.2235_2249del p.E746_A750del 19 --- --- +
6 Yes p.L858R 21 + --- +
7 No Wild type   --- --- ---
8 No Wild type   + --- ---
9 No Wild type   --- --- ---
10 No Wild type   --- --- +
11 No Wild type   --- + +
12 No Wild type   --- --- ---