Table 2 Staining of AC with established EGFR mutation status
From: Tuberous-sclerosis complex-related cell signaling in the pathogenesis of lung cancer
EGFR sequence alterations | Immunohistochemical analysis | |||||
|---|---|---|---|---|---|---|
No. | EGFR mutation | Mutation | Exon | TSC1 | P-TSC2 | P-mTOR |
1 | Yes | c.2573 T > G; p.L858R | 21 | --- | --- | --- |
2 | Yes | p.E746_P753 delinsIS c.2236_2259(24 bp)delinsATCTCG | 19 | + | + | + |
3 | Yes | c.2236_2250del p.E746_A750del | 19 | --- | --- | --- |
4 | Yes | p.L858R c.2573 T > G | 21 | --- | --- | + |
5 | Yes | c.2235_2249del p.E746_A750del | 19 | --- | --- | + |
6 | Yes | p.L858R | 21 | + | --- | + |
7 | No | Wild type | --- | --- | --- | |
8 | No | Wild type | + | --- | --- | |
9 | No | Wild type | --- | --- | --- | |
10 | No | Wild type | --- | --- | + | |
11 | No | Wild type | --- | + | + | |
12 | No | Wild type | --- | --- | --- | |