Table 1 Characteristics of 17 single nucleotide polymorphisms
From: Meta-analyses between 18 candidate genetic markers and overweight/obesity
Gene | SNP | Year | Author | Race | Cases/Controls (n) | Allele 1 | Allele 2 | Model selected | Heterogeneity | P value | Odds ratio (95% confidence interval) |
|---|---|---|---|---|---|---|---|---|---|---|---|
(Case/Controls, n) | (Case/Controls, n) | (I2)% | |||||||||
GNB3 | rs5443 | 1999 | Siffert W | Caucasian | 92/207 | 108/392 | 76/122 | Fixed | 42 | 0.47 | 1.04 (0.93-1.16) |
| Â | (C/T) | 1999 | Siffert W | Asian Chinese | 186/832 | 166/886 | 206/778 | ||||
| Â | Â | 1999 | Siffert W | African | 127/607 | 34/219 | 220/995 | ||||
| Â | Â | 2000 | Siffert W | Caucasian | 207/92 | 292/108 | 122/76 | ||||
| Â | Â | 2001 | Hinney A | Caucasian | 491/330 | 695/442 | 287/218 | ||||
| Â | Â | 2001 | Benjafield AV | Caucasian | 92/188 | 133/284 | 51/92 | ||||
| Â | Â | 2001 | Ohshiro Y | Asian Japanese | 208/150 | 215/148 | 201/152 | ||||
| Â | Â | 2004 | Suwazono Y | Asian Japanese | 505/2120 | 517/2177 | 493/2063 | ||||
| Â | Â | 2008 | Wang X | Asian Chinese | 129/270 | 442/285 | 376/255 | ||||
| Â | Â | 2013 | Hsiao TJ | Asian Chinese | 467/505 | 402/441 | 532/569 | ||||
MTHFR | rs1801133 | 2007 | Terruzzi I | Caucasian | 84/52 | 90/61 | 78/43 | Fixed | 0 | 0.59 | 1.05 (0.87-1.27) |
| Â | (C/T) | 2010 | Tavakkoly Bazzaz J | Asian Iranian | 74/207 | 109/306 | 39/108 | ||||
| Â | Â | 2012 | Yin RX | Asian Chinese | 751/978 | 1049/1383 | 453/573 | ||||
CNR1 | rs806381 | 2008 | Benzinou M | Caucasian | 839/1726 | 1163/2362 | 515/1090 | Fixed | 0 | 0.5 | 1.04 (0.93-1.17) |
| Â | (A/G) | 2008 | Jaeger JP | Caucasian | 430/317 | 613/464 | 247/170 | ||||
| Â | Â | 2012 | Zhuang M | Asian Chinese | 1662/1070 | 2345/1550 | 979/590 | ||||
BDNF | rs6265 | 2005 | Friedel S | Caucasian | 183/283 | 342/448 | 81/118 | Fixed | 46 | 0.8 | 1.01 (0.92-1.11) |
| Â | (G/A) | 2009 | Hotta K | Asian Japanese | 1127/1733 | 1367/2013 | 887/1453 | ||||
| Â | Â | 2009 | Marti A | Caucasian | 155/147 | 242/226 | 68/68 | ||||
| Â | Â | 2011 | Xi B | Asian Chinese | 1229/1619 | 1095/1554 | 1363/1684 | ||||
| Â | Â | 2011 | Rouskas K | Caucasian | 510/469 | 826/732 | 194/206 | ||||
| Â | Â | 2012 | Skledar M | Caucasian | 74/226 | 111/374 | 37/78 | ||||
FAAH | rs324420 | 2005 | Sipe JC | Caucasian | 1094/1594 | 1777/984 | 411/204 | Random | 79 | 0.54 | 0.94 (0.76-1.16) |
| Â | (C/A) | 2005 | Sipe JC | African | 507/107 | 687/161 | 327/53 | ||||
| Â | Â | 2005 | Sipe JC | Asian | 271/94 | 471/148 | 71/40 | ||||
| Â | Â | 2007 | Jensen DP | Caucasian | 4190/2507 | 6817/3991 | 1563/1023 | ||||
| Â | Â | 2008 | Durand E | Caucasian | 1517/1320 | 2473/2104 | 561/536 | ||||
| Â | Â | 2008 | Papazoglou D | Caucasian | 158/121 | 265/209 | 51/33 | ||||
| Â | Â | 2008 | Moneletone P | Caucasian | 378/110 | 614/194 | 142/26 | ||||
| Â | Â | 2010 | Muller TD | Caucasian | 2818/2818 | 3027/4607 | 689/1029 | ||||
ADRB1 | rs1801253 | 2001 | Rydén M | Caucasian | 141/157 | 206/214 | 76/100 | Fixed | 0 | 0.5 | 1.03 (0.94-1.14) |
| Â | (C/G) | 2004 | Tafel J | Caucasian | 296/134 | 403/180 | 189/88 | ||||
| Â | Â | 2007 | Gjesing AP | Caucasian | 4575/3073 | 6781/4609 | 2369/1537 | ||||
| Â | Â | 2008 | Ohshiro Y | Asian Japanese | 180/132 | 284/215 | 76/49 | ||||
SH2B1 | rs7498665 | 2009 | Hotta K | Asian Japanese | 1129/1735 | 1943/3003 | 315/467 | Fixed | 0 | 0.0004 | 1.21 (1.09-1.34) |
| Â | (A/G) | 2010 | Shi J | Asian Chinese | 829/1859 | 1427/3317 | 231/401 | ||||
| Â | Â | 2011 | Beckers S | Caucasian | 1045/317 | 1223/401 | 867/223 | ||||
| Â | Â | 2011 | Rouskas K | Caucasian | 510/469 | 673/675 | 347/263 | ||||
| Â | Â | 2012 | Volckmar AL | Caucasian | 3139/424 | 3728/557 | 2550/311 | ||||
PCSK1 | rs6232 | 2009 | Happé F | Caucasian | 3570/7933 | 6735/15028 | 405/838 | Fixed | 34 | 0.08 | 1.14 (0.97-1.12) |
| Â | (A/G) | 2011 | Rouskas K | Caucasian | 510/469 | 969/882 | 51/56 | ||||
|  |  | 2012 | Villalobos-Comparán M | South American Mexican | 1018/1364 | 2005/2709 | 31/19 | ||||
| Â | Â | 2013 | Choquet H | European American | 263/547 | 485/1041 | 41/53 | ||||
|  |  | 2013 | Dušátková L | Asian Czech | 668/770 | 1255/1469 | 81/71 | ||||
PCSK1 | rs6235 | 2009 | Happé F | Caucasian | 3559/7793 | 5164/11432 | 1954/4154 | Fixed | 0 | 0.26 | 1.04 (0.97-1.12) |
|  | (G/C) | 2012 | Villalobos-Comparán M | South America Mexican | 994/1336 | 1575/2156 | 413/516 | ||||
| Â | Â | 2013 | Choquet H | European - American | 263/547 | 368/793 | 158/301 | ||||
| Â | Â | 2013 | Choquet H | African - American | 453/251 | 740/432 | 166/70 | ||||
|  |  | 2013 | Dušátková L | Asian Czech | 670/772 | 996/1130 | 344/414 | ||||
| Â | Â | 2014 | Hsiao TJ | Asian Chinese | 290/175 | 406/229 | 174/121 | ||||
NPY2R | rs1047214 | 2006 | Torekov SS | Caucasian | 939/4767 | 1026/5295 | 852/4239 | Fixed | 0 | 0.54 | 0.97 (0.88-1.07) |
| Â | (T/C) | 2007 | Siddiq A | Caucasian | 953/1042 | 1048/1132 | 858/952 | ||||
| Â | Â | 2007 | Wang HJ | Caucasian | 184/183 | 189/169 | 179/197 | ||||
| Â | Â | 2009 | Zhang J | Asian Chinese | 705/1325 | 1171/2133 | 239/517 | ||||
FAIM2 | rs7138803 | 2009 | Hotta K | Asian Japanese | 1125/1726 | 1408/2251 | 842/1201 | Fixed | 0 | 0.04 | 1.11 (1.01-1.22) |
| Â | (G/A) | 2011 | Xi B | Asian Chinese | 1229/1619 | 1711/2332 | 747/906 | ||||
| Â | Â | 2011 | Rouskas K | Caucasian | 510/469 | 643/610 | 377/328 | ||||
| Â | Â | 2013 | Li C | Asian Chinese | 242/469 | 331/663 | 153/275 | ||||
| Â | Â | 2013 | Zhao XY | Asian Chinese | 371/393 | 534/565 | 208/221 | ||||
SERPINE1 | rs1799768 | 2001 | Sartori MT | Caucasian | 93/79 | 95/84 | 91/74 | Fixed | 39 | 0.07 | 0.83 (0.67-1.02) |
| Â | (4G/5G) | 2002 | Hoffstedt J | Caucasian | 317/188 | 305/141 | 329/235 | ||||
| Â | Â | 2006 | BerberoÄŸlu M | Asian Turk | 126/133 | 151/133 | 101/133 | ||||
|  |  | 2008 | Solá E | Caucasian | 67/67 | 70/65 | 64/69 | ||||
| Â | Â | 2008 | Kinik ST | Asian Turk | 39/38 | 52/36 | 26/40 | ||||
| Â | Â | 2011 | Espino A | South American Chilean | 50/71 | 32/51 | 44/52 | ||||
| Â | Â | 2012 | Wingeyer SD | South American Argentine | 110/111 | 92/109 | 128/113 | ||||
PON1 | rs854560 | 2011 | Veiga L | Caucasian | 81/74 | 101/90 | 61/58 | Fixed | 31 | 0.4 | 0.87 (0.62-1.21) |
| Â | (A/T) | 2011 | MartÃnez-Salazar MF | South American Mexican | 63/64 | 114/101 | 12/27 | ||||
|  |  | 2013 | Rupérez AI | Caucasian | 177/81 | 210/219 | 137/143 | ||||
PON1 | rs662 | 2011 | Veiga L | Caucasian | 81/74 | 68/44 | 94/104 | Fixed | 18 | 0.6 | 1.09 (0.79-1.51) |
| Â | (G/A) | 2011 | MartÃnez-Salazar MF | South American Mexican | 63/64 | 66/65 | 60/63 | ||||
|  |  | 2013 | Rupérez AI | Caucasian | 177/81 | 252/249 | 102/111 | ||||
CETP | TaqIB | 2006 | Huang ZY | Asian Chinese | 199/141 | 243/162 | 155/120 | Fixed | 0 | 0.23 | 0.91 (0.79-1.06) |
| Â | (B1/B2) | 2008 | Srivastava N | Asian Indian | 159/278 | 153/263 | 165/293 | ||||
| Â | Â | 2010 | Ruan X | Asian Chinese | 934/924 | 1104/1028 | 764/820 | ||||
| Â | Â | 2011 | Huang Y | Asian Chinese | 206/132 | 250/155 | 162/109 | ||||
UCP1 | rs1800592 | 1998 | Gagnon J | Caucasian | 674/311 | 1013/473 | 335/149 | Random | 60 | 0.23 | 1.19 (0.90-1.57) |
| Â | (A/G) | 2000 | Proenza AM | Asian Turk | 136/94 | 189/131 | 83/57 | ||||
|  |  | 2002 | Kieć-Wilk B | Caucasian | 12/106 | 18/146 | 6/66 | ||||
| Â | Â | 2002 | Nieters A | Caucasian | 154/153 | 232/231 | 76/75 | ||||
| Â | Â | 2003 | Forga Ll | Caucasian | 159/154 | 258/244 | 60/64 | ||||
| Â | Â | 2004 | Ramis JM | Caucasian | 82/170 | 259/433 | 49/81 | ||||
| Â | Â | 2008 | Mottagui-Tabar S | Caucasian | 91/479 | 433/736 | 149/222 | ||||
| Â | Â | 2009 | Shen ZN | Asian Chinese | 127/257 | 129/240 | 125/274 | ||||
ABCA1 | rs2230806 | 2006 | Porchay I | Caucasian | 2097/2947 | 2992/4238 | 1202/1656 | Fixed | 0 | 0.87 | 1.01 (0.90-1.13) |
| Â | (G/A) | 2007 | Kitjaroentham A | Asian Thai | 112/117 | 143/143 | 81/91 | ||||
| Â | Â | 2011 | Huang Y | Asian Chinese | 206/132 | 233/141 | 179/123 |