Table 2 Characteristics of APOE ϵ2/ϵ3/ϵ4 polymorphism
From: Meta-analyses between 18 candidate genetic markers and overweight/obesity
Year | Author | Race | Case/Controls (n) | Genotypes (case/controls, n) | Alleles (case/controls, n) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|  |  |  |  | ϵ2/ϵ2 | ϵ2/ϵ3 | ϵ2/ϵ4 | ϵ3/ϵ3 | ϵ3/ϵ4 | ϵ4/ϵ4 | ϵ2 | ϵ3 | ϵ4 |
2003 | Guerra A | Caucasian | 31/81 | 0/0 | 6/4 | 0/0 | 63/20 | 13/7 | 0/0 | 6/4 | 145/51 | 13/7 |
2008 | Srivastava N | Asian Indian | 159/278 | 0/1 | 17/18 | 2/6 | 90/198 | 41/55 | 9/0 | 19/30 | 238/469 | 61/61 |
2010 | Ergun MA | Asian Chinese | 38/42 | 0/2 | 2/0 | 12/4 | 8/9 | 16/26 | 0/1 | 14/8 | 34/44 | 28/32 |
2012 | Zhang J | Asian Chinese | 282/172 | 1/3 | 46/16 | 7/2 | 186/123 | 40/27 | 2/1 | 55/24 | 458/289 | 51/31 |
2012 | Zarkesh M | Asian Iran | 463/370 | 1/1 | 48/38 | 6/7 | 348/268 | 63/53 | 3/3 | 56/47 | 807/627 | 75/66 |
Module | Case/Controls (n) | Model selected | Heterogeneity (I2)% | P value | OR (95% CI) | Â | Â | Â | Â | Â | Â | Â |
ϵ2/ϵ2/ϵ3/ϵ3 | 954/813 | Fixed | 0 | 0.12 | 0.35 (0.09-1.32) |  |  |  |  |  |  |  |
ϵ2/ϵ3ϵ3/ϵ3 | 814/694 | Fixed | 48 | 0.07 | 1.33 (0.98-1.82) |  |  |  |  |  |  |  |
ϵ2/ϵ4/ϵ3/ϵ3 | 695/618 | Fixed | 0 | 0.92 | 0.96 (0.45-2.05) |  |  |  |  |  |  |  |
ϵ3/ϵ4/ϵ3/ϵ3 | 868/786 | Fixed | 28 | 0.7 | 1.05 (0.82-1.35) |  |  |  |  |  |  |  |
ϵ4/ϵ4/ϵ3/ϵ3 | 695/618 | Random | 63 | 0.54 | 1.89 (0.25-14.46) |  |  |  |  |  |  |  |
ϵ2/ϵ3 | 1832/1593 | Fixed | 23 | 0.26 | 1.16 (0.90-1.51) |  |  |  |  |  |  |  |
ϵ4/ϵ3 | 1910/1681 | Random | 65 | 0.54 | 1.13 (0.77-1.66 |  |  |  |  |  |  |  |