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Table 1 Summary of MCPyV- ST expressions in MCPyV- LT DNA- positive and -negative MCCs

From: A new in situ hybridization and immunohistochemistry with a novel antibody to detect small T-antigen expressions of Merkel cell polyomavirus (MCPyV)

    MCPyV-LT MCPyV-ST
Case no. Age (years) Sex LT-DNA IHC (CM2B4) ST-DNA ST-mRNA IHC (ST-1)
  Real-time PCR* Conventional PCR Real-time PCR* ISH Nuclear Cytoplasm
MCC32 66 M 1.20 + + 2.11 + ++ ++
MCC33 66 M 1.48 + + 0.57 + + ++
MCC36 87 F 0.20 + + 4.84 + + -
MCC37 73 F 0.87 + + 1.97 + - ++
MCC47 90 M 0.06 + + 3.13 + - +
MCC65 NA F 1.50 + + 2 + + +
MCC68 NA M 11.94 + + 13.29 + - +
MCC70 NA M 14.40 + + 4.03 + ++ +
MCC72 72 F 0.99 + + 2.62 + - +
MCC74 62 M 0.20 + - 3.14 + - +
MCC UK9 69 M 65.62 + + 0.96 f+ + -
MCC UK11 61 F 3.81 - + 6.97 f+ + ++
MCC UK16 63 F 127.24 + + 8.16 + + ++
MCC UK19 85 F 93.19 + + 1.11 + + ++
MCCU K21 46 F 51.82 + + 6.6 - ++ ++
MCC UK22 74 F 178.81 + + 1.68 + + +
MCC50 82 M - - - ND - - +
MCC63 NA M - - - ND - - ++
MCC64 NA F - f+ - - - - +
MCC UK1 81 F - - - ND - - +
MCC UK2 81 F - - - ND - - ++
MCC UK3 85 F - - - ND - - +
MCC UK4 93 F - - - ND - - +
MCC UK6 82 M - - - ND - - ++
MCC UK8 87 F - - - ND - - +
MCC UK10 94 F - - - ND - - ++
MCC UK12 80 M - - - ND - - +
MCC UK13 61 M - - - ND - - ++
MCC UK14 86 F - - - ND - - ++
MCC UK15 83 F - - - ND - - ++
MCC UK17 83 F - - - ND - - +
MCC UK18 94 F - - - ND - - ++
  1. Abbreviations: IHC immunohistochemistry, ISH in situ hybridization.
  2. NA, not available; ND, not done; *, copies per cell; f+, focally positive.