Figure 1

Genetic abnormalities detected by multi-color FISH in primary breast cancer. p53, Mdmx and Mdm2 were labeled with green, orange and red respectively (A) Low level of Mdmx amplification accompanied with normal gene copy number of p53 and Mdm2 is shown, most cancer cell nuclei have <10 orange signals (FISH,×630). (B) The tumor cells lack of gene number changes of Mdmx and Mdm2 show LOH of p53, most cancer cell nuclei have only 1 green signal (FISH,×630).