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Table 2 Allelic and genotypic associations between three selected SNPs and AMD

From: Association study of newly identified age-related macular degeneration susceptible loci SOD2, MBP, and C8orf42 in Han Chinese population

SNP information

Allelic associations

Genotypic associations

dbSNP ID

Gene

chr:pos

Location

Allelesa

Effective allele frequency

P valueb

Genotypic distributions

P valuec

P valued

         

OR (95% CI)

   

OR (95% CI)

OR (95% CI)

rs2842992

SOD2

6:160071159

Intergenic

A/G

Case

0.523

GA case

0.547

0.277

AA/AG/GG

Case

47/107/38

0.266

0.661

     

Control

0.558

Non-GA case

0.508

0.87 (0.67-1.13)

 

Control

109/165/69

0.87 (0.67-1.12)

0.93 (0.68-1.28)

rs1789110

MBP

18:74859044

Intergenic

A/C

Case

0.542

GA case

0.533

0.850

AA/AC/CC

Case

55/107/38

0.798

0.537

     

Control

0.535

Non-GA case

0.548

1.03 (0.80-1.33)

 

Control

100/171/76

1.03 (0.80-1.33)

1.10 (0.81-1.51)

rs722782

C80rf42

8:516479

Intergenic

A/C

Case

0.473

GA case

0.471

0.281

AA/AC/CC

Case

43/92/53

0.279

0.080

     

Control

0.508

Non-GA case

0.475

0.87 (0.67-1.12)

 

Control

97/177/91

0.87 (0.68-1.12)

0.76 (0.56-1.03)

  1. Abbreviations: chr:pos chromosome:position, OR odds ratio, CI confidence interval.
  2. aEffective alleles are indicated in bold type, and odds ratios were calculated based on this allele.
  3. bORs, 95% CIs and P values were calculated based on Fisher’s exact test.
  4. cORs, 95% CIs and P values were calculated using logistic regression, assuming the additive model.
  5. dORs, 95% CIs and P values were calculated using logistic regression, assuming the additive model with adjustment for age.