Table 1 Summary of total 18 cases of sporadic multiple ossifying fibromas

1

Bradley and Leake [38], 1968

F/6

Les. 1: rught maxilla Les. 2: right angle of the mandible

P.R.: multicystic Lesions

Yes/N.S.

N.S.

Right maxilla:enucleation and curettage right mandible: scheduled for removal

N.S.

N.S.

N.S.

2

Takeda and Fujioka [39], 1987

M/55

Les. 1: left maxilla Les. 2: right maxilla

P.R: well-circumscribed lesions showed radiolucent areas mixed with radiopaque areas

N.S.

N.S.

N.S.

Patient refused treatment

N.S.

N.S.

3

Hauser et al [40], 1989

M/35

Les. 1: right maxillary sinus Les. 2: left maxillary sinus

P.R.: well-circumscribed mixed radiolucent/radiopaque lesions CT: well-circumscribed lesion with calcified masses

No/N.S.

N.S.

Right maxillary sinus: enucleation left maxillary sinus: partial hemimaxillectomy

N.S.

N.S.

N.S.

4

Yih et al [41], 1989

F/31

Les. 1: left mandible Les. 2: right maxilla Les. 3: left mandible (2 years later)

P.R.: well circumscribed unilocular radiolucency

N.S.

ALP: 218 IU/L↑Ca : normal limits P: normal limits

Left mandibular body and right maxilla:enucleation

Recurrence of the left mandible after 2 y later

N.S.

N.S.

5

Khanna and Andrade [42], 1992

M/33

Les. 1: right maxilla Les. 2: left mandible

P.R.: large lesions contained diffused calcifications

N.S.

ALP: normal limits Ca: normal limits

Both of the two lesions: enucleation

Lost for follow-up

N.S.

N.S.

6

Hwang et al [43], 2001

F/25

Les. 1: right mandible Les. 2: left maxilla Les. 3: left mandibuar body Les. 4: left maxilla Les. 5: right maxilla

P.R.: large calcified mass surrounded by a radiolucent halo zone with corticated margin

Yes/yes

N.S.

Right mandible: partial hemimandibulectomy right maxilla:hemimaxillectomy

Initially refused treatment; 3 y later, surgical remission of the lesions was undertaken

N.S.

N.S.

7

Bertolini et al [44], 2002

F/37

Les. 1: left maxilla. and hard palate Les. 2: right mandible Les. 3: left mandible

P.R.: large radiolucency lesions with interspersed calcifications CT: revealed fibrous calcified masses that involved the left maxilla and the right and left mandibular body

No/no

N.S.

Right mandible: partial mandibulectomy Left mandible: curettage Left maxilla: intraoral surgical removal

Mandible: no recurrencey after 2 y Maxilla.: no recurrence after 1 y

N.S.

N.S.

8

Barberi et al [45], 2003

F/53

Les. 1: left infraorbital region Les. 2: right hard palate

P.R.: showed partial opacification of left maxillary sinus CT: two different multilocular, inhomogeneously hypodense entities walled in an irregularly thick sclerotic border

No /no

N.S.

N.S.

N.S.

N.S.

N.S.

9

Stergiou et al [46], 2007

F/36

Les. 1: left mandible Les. 2: right mandible Les. 3: left maxilla

P.R.: well circumscribed unilocular radiolucency containing diffuse calcifications CT: well demarcated lesions, low density and scattered calcifications

N.S.

N.S.

Enucleation and curettage

No recurrence after 6 months

N.S.

N.S.

10

Chindia et al [47], 2008

F/27

Les. 1: right angle and body of the mandible Les. 2: left maxilla

P.R.: mandibular lesion was corticated and maxillary lesion was less well defined with almost complete obliteration of the maxillary sinus

N.S.

N.S.

Both of the lesions: enucleation

Recurrence after 6 months (mandible)

N.S.

N.S.

11

Ribeiro et al [48], 2011

F/35

Les. 1: left mandible Les. 2: right mandible

P.R.: large radiolucency surrounded by a radiopaque halo in the left and right mandible CT: unilocular and hypodense image

Yes/yes

Ca: 9.73 mg/dl P: 4.2 mg/dL PTH: 56.34 pg/mL

Both lesions: enucleation

No recurrence after 3 y

N.S.

N.S.

12

Agarwal et al [50], 2012

F/20

Les. 1: left posterior maxilla Les. 2: right posterior mandible

P.R.: maxillary and mandibular lesion was well-defined with a radiolucent rim and sclerotic border CT: hyperattenuated masses in left maxillary and right mandibular alveolar ridges

Yes/no

N.S.

N.S.

Take an operation fifteen years ago of maxilla

N.S.

N.S.

13

Popli et al [21], 2012

F/19

Les. 1: left maxilla Les. 2: right mandible

P.R.: well-defined mixed radiolucent and radiopaque lesions CT: mixed-density, expansile lesions present at the alveolar process of both the maxilla walled by irregularly thick sclerotic border.

Yes/yes

No sign of hyperparathyroidism

Enucleation

No recurrence after 2 y

N.S.

N.S.

14

Akcam et al [49], 2012

M/20

Les. 1: left maxilla Les. 2: left mandible

P.R.: well defined,multilocular radiolucent lesion of the left mandible unilocular radiolucent lesion in the left maxilla CT: extensivehypodense lesions with cortical expansion

Yes/no

Ca, P, PTH within normal limits

Enucleation

No recurrence after 8 months

N.S.

N.S.

15

Kiran Desai et al [22], 2013

F/18

Les. 1: right maxilla Les. 2: right mandible

CT: large well-defined expansile lesion, heterogeneously hyper dense, multiple internal punctuate calcifications

Yes/N.S.

Blood calcium levels within normal limits, no sign of hyperparathyroidism

Enucleation

No recurrence after 2 years

N.S.

N.S.

16

Ponniah et al [23], 2013

F/45

mutiple lesions from the left mandible to the right mandible

P.R.: multilocular radiolucent lesion CT: osteolytic, soft-tissue density lesion with thinning and erosion of the buccal cortex in the anterior region of the mandible

Yes/yes

N.S.

Enucleation

No recurrence after 5 months

N.S.

N.S.

17

Present case 1

F/15

Les.1: right maxilla Les. 2, 3: bilateral mandible

P.R.: well demarcated radiolucency in the bilateral mandible

Yes/yes

Ca: 2.7 mmol/L P: 0.77 mmol/L↓ ALP: 278 IU/L↑, PTH not find to text

Enucleation

Recurrence after 1 year

No

No

18

Present case 2

M/6

Les. 1: right maxilla Les. 2: left maxilla Les. 3: right mandible Les. 4: left mandible

P.R.:central inhomogeneous mineralizationin thin marginal radiolucent area with a well demarcated sclerotic border CT: mixed radiopaque image

Yes/yes

Ca: 2.63 mmol/L P: 1.58 mmol/L ALP: 62 IU/L PTH 9.12 pg/mL

Incisional biopsies the treatment delayed because of the young age

After 1 year, the lesions enlarged obviously

No

No