CD44v/CD44s expression patterns are associated with the survival of pancreatic carcinoma patients

Li, Zhonghu; Chen, Kai; Jiang, Peng; Zhang, Xi; Li, Xiaowu; Li, Zhihua

doi:10.1186/1746-1596-9-79

Diagnostic Pathology

Table 1 Associations between the status of CD44 variants and CD44s and the categorical clinicopathological parameters of pancreatic carcinoma (n = 101)

From: CD44v/CD44s expression patterns are associated with the survival of pancreatic carcinoma patients

Parameters	CD44v2		CD44v3		CD44v4		CD44v5		CD44v6		CD44v7		CD44v8		CD44v9		CD44v10		CD44s
Parameters	+	-	+	-	+	-	+	-	+	-	+	-	+	-	+	-	+	-	+	-
Gender
P-value	0.379		0.379		0.956		0.68		0.956		0.178		0.956		0.956		0.322		0.379
Male/Female	40/10	37/14	40/10	37/14	39/12	38/12	39/11	38/13	39/12	38/12	41/9	36/15	38/12	39/12	39/12	38/12	41/10	36/14	40/10	37/14
Age, years
P-value	0.875		0.551		0.551		0.777		0.777		0.551		0.551		0.777		0.47		0.551
<65/≥65	36/14	36/15	37/13	35/16	37/13	35/16	35/15	37/14	37/14	35/15	37/13	35/16	37/13	35/16	37/14	35/15	38/13	34/16	37/13	35/16
Tumor location
P-value	0.353		0.796		0.737		0.737		0.796		0.796		0.796		0.737		0.737		0.353
Head/Body,tail	42/8	46/5	44/6	44/7	45/6	43/7	43/7	45/6	44/7	44/6	44/6	44/7	44/6	44/7	45/6	43/7	45/6	43/7	42/8	46/5
Tumor size, cm
P-value	0.9		0.593		0.489		0.346		0.489		0.9		0.9		0.9		0.593		0.271
≤2/>2	19/31	20/31	18/32	21/30	18/33	21/29	17/33	22/29	18/33	21/29	19/31	20/31	19/31	20/31	20/31	19/31	21/30	18/32	22/28	17/34
Lymphatic invasion
P-value	0.625		0.197		0.055		0.197		0.02		0.09		0.09		0.02		0.129		0.474
Neg/Pos	27/23	30/21	25/25	32/19	24/27	33/17	25/25	32/19	23/28	34/16	24/26	33/18	24/26	33/18	23/28	34/16	25/26	32/18	30/20	27/24
Vascular invasion
P-value	0.006		0.408		0.408		0.702		0.951		0.408		0.951		0.702		0.951		0.203
Neg/Pos	30/20	43/8	38/12	35/16	35/16	38/12	37/13	36/15	37/14	36/14	38/12	35/16	36/14	37/14	36/15	37/13	37/14	36/14	39/11	34/17
Neural invasion
P-value	0.875		0.875		0.777		0.3		0.875		0.777		0.551		0.245		0.875		0.47
Neg/Pos	36/14	36/15	36/14	36/15	37/14	35/15	38/12	34/17	36/15	36/14	35/15	37/14	37/13	35/16	39/12	33/17	36/15	36/14	34/16	38/13
Duodenal invasion
P-value	0.295		0.583		0.653		0.653		0.295		0.295		0.653		0.583		0.961		0.147
Neg/Pos	38/12	43/8	39/11	42/9	40/11	41/9	41/9	40/11	43/8	38/12	38/12	43/8	41/9	40/11	42/9	39/11	41/10	40/10	43/7	38/13
Hepatic metastases
P-value	0.484		0.042		0.049		0.172		0.049		0.049		0.042		0.049		0.049		0.049
Neg/Pos	44/6	47/4	42/8	49/2	43/8	48/2	43/7	48/3	43/8	48/2	43/7	48/3	42/8	49/2	43/8	48/2	43/8	48/2	48/2	43/8
Differentiation
P-value	0.808		0.1		0.507		0.124		0.202		0.927		0.491		0.696		0.428		0.028
Poor	13	16	18	11	17	12	19	10	15	14	14	15	15	14	13	16	16	13	11	18
Middle	32	31	26	37	29	34	27	36	29	34	31	32	29	34	32	31	29	34	31	32
Well	5	4	6	3	5	4	4	5	7	2	5	4	6	3	6	4	6	3	8	1
Stage (UICC)
P-value	0.837		0.109		0.057		0.135		0.008		0.286		0.061		0.027		0.143		0.028
IA/IB	4/11	6/14	3/13	7/12	2/12	8/13	2/13	8/12	2/13	8/12	3/12	7/13	4/12	6/13	4/11	6/14	4/12	6/13	6/18	4/7
IIA/IIB	9/20	6/20	4/22	11/18	5/24	10/16	5/23	10/17	3/25	12/15	5/23	10/17	3/23	12/17	3/25	12/15	4/23	11/17	4/19	11/21
III/IV	0/6	0/5	0/8	0/3	0/8	0/3	0/7	0/4	0/8	0/3	0/7	0/4	0/8	0/3	0/8	0/3	0/8	0/3	0/3	0/8

The bold values indicate P-values less than 0.05, Neg (−): negative, Pos(+): positive, UICC Union for International Cancer Control.

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ISSN: 1746-1596

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