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Table 3 Subgroup analysis of insulin use and CRC incidence with combined RR

From: Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients: a systemic review and meta-analysis

 

No. of studies

Summary effect

Study heterogeneity

RR

95% CI

P

I 2

Study design

Cohort

5

1.25

0.95-1.65

0.002

75.7

Case–control

7

2.15

1.41-3.26

<0.001

89.1

Geographic location

Europe

3

1.20

0.92-1.57

0.001

85.8

America

5

1.73

1.15-2.60

0.014

67.8

Asia

4

2.55

2.14-3.04

0.373

3.9

Gender

Male

3

1.02

0.90-1.16

0.512

0.0

Female

3

1.14

0.73-1.77

0.026

72.5

  1. RR, relative risk; CI, confidence interval.