Berberine increases radiosensitivity of LNCaP xenografts. (A) Measurement of body weight in nude mice once per week. (B) Measurement of tumor volume in nude mice every four days. Data were presented as the relative tumor volume normalized to the initial tumor volume measured on day 0. (C) Measurement of tumor weight in the nude mice after sacrifice. P < 0.005, IR vs. berberine (5 or 10 mg/kg) + IR, (D) Visual observation of the tumors in each group. (E) Western blots showing the expression of HIF-1α and VEGF in LNCaP mouse xenograft tissues. Ber: berberine, 5: 5 mg/kg, 10: 10 mg/kg, IR: 8 Gy.