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Table 1 Effect of berberine on response of ECA109 xenografted tumor to irradiation

From: Berberine inhibits the expression of hypoxia induction factor-1alpha and increases the radiosensitivity of prostate cancer

Treatment

n

Inhibition (%)*

Doubling time (days)**

Absolute growth delay (days)***

Normalized growth delay (days)

Enhancement factor

Control

5

 

10.8 ± 1.2

   

Ber5

5

27.6 ± 6.3

12.3 ± 2.5

1.5(12.3-10.8)

  

Ber10

5

58.1 ± 8.6

13.1 ± 3.0

2.3(13.1-10.8)

  

IR

5

37.8 ± 6.9

16.5 ± 1.5

5.7(16.5-10.8)

  

IR + Ber5

5

66.6 ± 9.2

21.4 ± 0.7

10.6(21.4-10.8)

9.1(10.6-1.5)

1.6(9.1/5.7)

IR + Ber10

5

75.9 ± 5.9

22.7 ± 4.6

11.9(22.7-10.8)

9.6(11.9-2.3)

1.7(9.6/5.7)

  1. *Tumor growth inhibition rate was calculated based on the tumor volume on Day 40.
  2. **Absolute growth delay: The doubling tumor time of treatment group minus that of control group;
  3. ***Normalized growth delay: The time of absolute growth delay of tumor in IR combined with Ber group minus that of Ber group.