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Table 1 Effect of berberine on response of ECA109 xenografted tumor to irradiation

From: Berberine inhibits the expression of hypoxia induction factor-1alpha and increases the radiosensitivity of prostate cancer

Treatment n Inhibition (%)* Doubling time (days)** Absolute growth delay (days)*** Normalized growth delay (days) Enhancement factor
Control 5   10.8 ± 1.2    
Ber5 5 27.6 ± 6.3 12.3 ± 2.5 1.5(12.3-10.8)   
Ber10 5 58.1 ± 8.6 13.1 ± 3.0 2.3(13.1-10.8)   
IR 5 37.8 ± 6.9 16.5 ± 1.5 5.7(16.5-10.8)   
IR + Ber5 5 66.6 ± 9.2 21.4 ± 0.7 10.6(21.4-10.8) 9.1(10.6-1.5) 1.6(9.1/5.7)
IR + Ber10 5 75.9 ± 5.9 22.7 ± 4.6 11.9(22.7-10.8) 9.6(11.9-2.3) 1.7(9.6/5.7)
  1. *Tumor growth inhibition rate was calculated based on the tumor volume on Day 40.
  2. **Absolute growth delay: The doubling tumor time of treatment group minus that of control group;
  3. ***Normalized growth delay: The time of absolute growth delay of tumor in IR combined with Ber group minus that of Ber group.