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Figure 2 | Diagnostic Pathology

Figure 2

From: Immunohistochemical assessment of a unique basal pattern of p53 expression in ulcerative-colitis-associated neoplasia using computer-assisted cytometry

Figure 2

Basal positivity of p53 in representative cases of UC-IIa, IIb, and III. (A) UC-IIa showing mild glandular distortion with slight nuclear enlargement and hyperchromatism at the bottom of crypts. There is no nuclear stratification or mucin depletion. Moderate small round cell infiltration with crypt abscess is present in the lamina mucosae (H&E, original magnification × 10). (B) Weak intensity of p53 staining is restricted to the lower third of the crypts (serial sections of ‘A’; immunoperoxidase, original magnification × 10). (C) UC-IIb demonstrating hyperchromatic and enlarged nuclei with slight stratification and occasional goblet cell depletion in the lower half of the crypts. Mild to moderate inflammation is seen in the background mucosa (H&E, original magnification × 10). (D) p53 positivity is limited to the lower half of the crypts (serial section of ‘C’; immunoperoxidase, original magnification × 10). (E) UC-III shows marked hyperchromatic and stratified nuclei with some variation in size and shape from the bottom of the crypt to the surface epithelium. Marked goblet cell depletion with mild inflammation is present in the mucosa (H&E, original magnification × 10). (F) Strong p53 expression is identified in the lower two thirds of the crypts (serial section of ‘E’; immunoperoxidase, original magnification × 10).

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