Table 3
From: Correlation of EGFR expression, gene copy number and clinicopathological status in NSCLC
| Â | Total N (%) | Dako pharmDx | 31G7 | 2.1E1 | SP84 | FISH | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A | B | C | A | B | C | A | B | C | A | B | C | + | |||
Age | ≥65 | 128(62) | 84(40.8) | 112(54.4) | 118(57.3) | 90(43.7) | 112(54.4) | 117(56.8) | 112(54.4) | 119(57.8) | 119(57.5) | 72(35) | 98(47.6) | 113(54.9) | 26(12.6) |
<65 | 78(38) | 45(21.8) | 64(31.1) | 66(32) | 47(22.8) | 64(31.1) | 68(33) | 65(31.6) | 69(33.5) | 71(34.5) | 40(19.4) | 62(30.1) | 68(33) | 16(7.8) | |
| Â | P value | 0.299 | 0.312 | 0.105 | 0.171 | 0.312 | 0.350 | 0.416 | 0.312 | 0.789 | 0.564 | 0.731 | 0.829 | 1 | |
Sex | Male | 132(64) | 81(39.3) | 115(55.8) | 121(58.7) | 85(41.3) | 116(56.3) | 123(59.7) | 115(55.8) | 124(60.2) | 125(60.7) | 75(36.4) | 109(52.9) | 120(58.3) | 24(11.7) |
Female | 74(36) | 48(23.3) | 61(29.6) | 63(30.6) | 52(25.2) | 60(29.1) | 62(30.1) | 62(30.1) | 64(31.1) | 65(31.6) | 37(18) | 51(24.8) | 61(29.6) | 18(8.7) | |
| Â | P value | 0.655 | 0.412 | 0.163 | 0.443 | 0.218 | 0.052 | 0.535 | 0.077 | 0.103 | 0.383 | 0.036 | 0.080 | 0.368 | |
Histology | ADC | 100(48.6) | 53(25.7) | 82(39.8) | 88(42.7) | 58(28.2) | 81(39.3) | 89(43.2) | 83(40.3) | 90(43.7) | 91(44.2) | 42(20.4) | 67(32.5) | 85(41.3) | 23(11.2) |
SCC | 86(41.7) | 69(33.5) | 82(39.8) | 84(40.8) | 70(34) | 83(40.3) | 84(40.8) | 83(40.3) | 84(40.8) | 85(41.3) | 65(31.6) | 82(39.8) | 84(40.8) | 17(8.3) | |
LCC | 12(5.8) | 6(2.9) | 9(4.4) | 9(4.4) | 7(3.4) | 9(4.4) | 9(4.4) | 8(3.9) | 9(4.4) | 9(4.4) | 5(2.4) | 9(4.4) | 9(4.4) | 2(1) | |
Other | 8(3.9) | 1(0.5) | 3(1.5) | 3(1.5) | 2(1) | 3(1.5) | 3(1.5) | 3(1.5) | 5(2.4) | 5(2.4) | 0(0) | 2(1) | 3(1.5) | 0(0) | |
| Â | P value | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.001 | 0.000 | 0.000 | 0.000 | 0.000 | 0.567 | |
ADC subtypes | Acinar | 38(18.4) | 21(21) | 30(30) | 33(33) | 24(24) | 32(32) | 33(33) | 31(31) | 33(33) | 33(33) | 16(16) | 26(26) | 34(34) | 11(11) |
Solid | 25(12.1) | 11(11) | 19(19) | 21(21) | 12(12) | 19(19) | 22(22) | 19(19) | 22(22) | 22(22) | 8(8) | 16(16) | 21(21) | 2(2) | |
Papillary | 22(10.8) | 15(15) | 21(21) | 22(22) | 16(16) | 21(21) | 22(22) | 22(22) | 22(22) | 22(22) | 12(12) | 17(17) | 20(20) | 7(7) | |
Micro papillary | 10(4.9) | 4(4) | 8(8) | 8(8) | 4(4) | 6(6) | 8(8) | 8(8) | 9(9) | 9(9) | 4(4) | 5(5) | 6(6) | 1(1) | |
Invasive mucinous | 3(1.4) | 1(19 | 2(2) | 2(2) | 1(1) | 2(2) | 2(2) | 2(2) | 2(2) | 2(2) | 1(1) | 2(2) | 2(2) | 2(2) | |
Lepidic | 2(1) | 1(1) | 2(2) | 2(2) | 1(1) | 1(1) | 2(2) | 1(1) | 2(2) | 3(3) | 1(1) | 1(1) | 2(2) | 0(0) | |
| Â | P value | 0.516 | 0.348 | 0.181 | 0.302 | 0.041 | 0.201 | 0.029 | 0.258 | 0.499 | 0.751 | 0.438 | 0.189 | 0.029 | |
Grade | Well | 5(2.4) | 2(1) | 3(1.5) | 3(1.5) | 2(1) | 2(1) | 3(1.5) | 2(1) | 3(1.5) | 3(1.5) | 2(1) | 2(1) | 3(1.5) | 1(0.5) |
Moderate | 82(39.8) | 55(26.7) | 71(34.5) | 73(35.4) | 60(29.1) | 72(35) | 74(35.9) | 74(35.9) | 76(36.9) | 77(37.4) | 46(22.3) | 67(32.5) | 72(35) | 17(8.3) | |
poor | 119(57.8) | 72(35) | 102(49.5) | 108(52.4) | 75(36.4) | 102(49.5) | 108(52.4) | 101(49) | 109(52.9) | 110(53.4) | 64(31.1) | 91(44.2) | 106(51.5) | 24(11.7) | |
| Â | P value | 0.371 | 0.268 | 0.107 | 0.148 | 0.020 | 0.126 | 0.009 | 0.62 | 0.047 | 0.789 | 0.075 | 0.155 | 1 | |
Tumor size | T1 | 39(18.9) | 24(11.7) | 30(14.6) | 31(15) | 25(12.1) | 31(15) | 32(15.5) | 30(14.6) | 33(16) | 34(16.5) | 20(9.7) | 28(13.6) | 31(15) | 5(2.4) |
T2 | 115(55.9) | 71(34.5) | 99(48.1) | 105(51) | 78(37.9) | 99(48.1) | 104(50.5) | 100(48.5) | 104(50.5) | 105(51) | 61(29.6) | 90(43.7) | 102(49.5) | 24(11.7) | |
T3 | 32(15.5) | 21(10.2) | 30(14.6) | 31(15) | 20(9.7) | 29(14.1) | 31(15) | 28(13.6) | 31(15) | 31(15) | 17(8.3) | 24(11.7) | 29(14.1) | 7(3.4) | |
T4 | 20(9.8) | 13(6.3) | 17(8.3) | 17(8.3) | 14(6.8) | 17(8.3) | 18(8.7) | 19(9.2) | 20(9.7) | 20(9.7) | 14(6.8) | 18(8.7) | 19(9.2) | 6(2.9) | |
| Â | P value | 0.982 | 0.271 | 0.080 | 0.919 | 0.615 | 0.234 | 0.293 | 0.181 | 0.309 | 0.539 | 0.444 | 0.362 | 0.449 | |
Lymph node | N0 | 99(48) | 66(32) | 82(39.8) | 86(41.7) | 66(32) | 82(39.8) | 86(41.7) | 82(39.8) | 88(42.7) | 88(42.7) | 54(26.2) | 75(36.4) | 84(40.8) | 14(6.8) |
N1 | 49(23.8) | 30(14.6) | 43(20.9) | 46(22.3) | 31(15) | 43(20.9) | 46(22.3) | 44(21.4) | 46(22.3) | 46(22.3) | 26(12.6) | 39(18.9) | 44(21.4) | 13(6.3) | |
N2 | 43(20.9) | 24(11.7) | 38(18.4) | 38(18.4) | 27(13.1) | 37(18) | 39(18.9) | 37(18) | 40(19.4) | 41(19.9) | 25(12.1) | 33(16) | 39(18.9) | 12(5.8) | |
N3 | 15(7.3) | 9(4.4) | 13(6.3) | 14(6.8) | 13(6.3) | 14(6.8) | 14(6.8) | 14(6.8) | 14(6.8) | 15(7.3) | 7(3.4) | 13(6.3) | 14(6.8) | 3(1.5) | |
| Â | P value | 0.643 | 0.835 | 0.667 | 0.358 | 0.765 | 0.645 | 0.652 | 0.833 | 0.460 | 0.892 | 0.843 | 0.741 | 0.151 | |
Stage | I | 68(33) | 45(21.8) | 57(27.7) | 60(29.1) | 47(22.8) | 59(28.6) | 60(29.1) | 59(28.6) | 62(30.1) | 62(30.1) | 36(17.5) | 53(25.7) | 58(28.2) | 8(3.9) |
II | 57(27.7) | 32(15.5) | 46(22.3) | 50(24.3) | 34(16.5) | 44(21.4) | 49(23.8) | 45(21.8) | 49(23.8) | 49(23.8) | 27(13.1) | 40(19.4) | 47(22.8) | 13(6.3) | |
III | 73(35.4) | 45(21.8) | 66(32) | 67(32.5) | 50(24.3) | 66(32) | 68(33) | 65(31.6) | 69(33.5) | 71(34.5) | 44(21.4) | 60(29.1) | 68(33) | 18(8.7) | |
IV | 8(3.9) | 7(3.4) | 7(3.4) | 7(3.4) | 6(2.9) | 7(3.4) | 8(3.9) | 8(3.9) | 8(3.9) | 8(3.9) | 5(2.4) | 7(3.4) | 8(3.9) | 3(1.5) | |
| Â | P value | 0.337 | 0.406 | 0.771 | 0.635 | 0.192 | 0.493 | 0.317 | 0.380 | 0.093 | 0.494 | 0.403 | 0.194 | 0.095 | |
Smoking behavior | Current | 78(56.1) | 52(43.3) | 71(59.2) | 72(60) | 55(45.8) | 70(58.3) | 72(60) | 71(59.2) | 72(60) | 72(60) | 44(36.7) | 67(55.8) | 72(60) | 16(13.3) |
Former | 30(21.6) | 22(18.3) | 27(22.5) | 28(23.3) | 23(19.2) | 27(22.5) | 29(24.2) | 27(22.5) | 29(24.2) | 29(24.2) | 19(15.8) | 26(21.7) | 29(24.2) | 4(3.3) | |
Never | 12(8.6) | 6(5) | 9(7.5) | 9(7.5) | 6(5) | 9(7.5) | 9(7.5) | 9(7.5) | 9(7.5) | 10(8.3) | 5(4.2) | 7(5.8) | 8(6.7) | 2(1.7) | |
| Â | P value | 0.342 | 0.254 | 0.150 | 0.254 | 0.373 | 0.078 | 0.254 | 0.078 | 0.368 | 0.494 | 0.055 | 0.014 | 0.729 | |
Asbestos contact | Present | 18(20.5) | 14(20.3%) | 17(24.6) | 17(24.6) | 14(20.3) | 17(24.6%) | 17(24.6) | 16(23.2) | 17(24.6%) | 17(24.6) | 12(17.4) | 16(23.2%) | 18(26.1) | 3(4.3) |
Absent | 51(58) | 37(53.6%) | 45(65.2) | 45(65.2) | 38(55.1) | 44(63.8%) | 46(66.7) | 44(63.8) | 46(66.7%) | 46(66.7) | 28(40.5) | 40(58%) | 46(66.7) | 14(20.3) | |
| Â | P value | 0.763 | 0.667 | 0.667 | 1.000 | 0.441 | 0.681 | 1.000 | 0.681 | 0.681 | 0.421 | 0.489 | 0.316 | 0.528 | |