Table 5 Association between IHC using three different scoring methods and FISH analysis
From: Correlation of EGFR expression, gene copy number and clinicopathological status in NSCLC
EGFR IHC | FISH | Total | P value | |||
|---|---|---|---|---|---|---|
Positive | Negative | |||||
Dako PharmDx | Score(A) | Positive | 34(16.5%) | 95(46.1%) | 129(62.6%) 77(37.4%) | 0.007 |
Negative | 8(3.9%) | 69(33.5%) | ||||
Score(B) | Positive | 41(19.9%) | 135(65.5%) | 176(85.4%) 30(14.6%) | 0.012 | |
Negative | 1(0.5%) | 29(14.1%) | ||||
Score(C) | Positive | 42(20.4%) | 142(68.9%) | 184(89.3%) 22(10.7%) | 0.009 | |
Negative | 0(0%) | 22(10.7%) | ||||
31G7 | Score(A) | Positive | 34(16.5%) | 61(29.6%) | 95(46.1%) 111(53.9%) | 0.028 |
Negative | 8(3.9%) | 103(50%) | ||||
Score(B) | Positive | 42(20.4%) | 134(65%) | 176(85.4%) 30(14.6%) | 0.001 | |
Negative | 0(0%) | 30(14.6%) | ||||
Score(C) | Positive | 42(20.4%) | 143(69.4%) | 185(89.8%) 21(10.2%) | 0.009 | |
Negative | 0(0%) | 21(10.2%) | ||||
2.1E1 | Score(A) | Positive | 41(19.9%) | 136(66%) | 177(85.9%) 29(14.1%) | 0.012 |
Negative | 1(0.5%) | 28(13.6%) | ||||
Score(B) | Positive | 42(20.4%) | 146(70.9%) | 188(91.3%) 18(8.7%) | 0.027 | |
Negative | 0(0%) | 18(8.7%) | ||||
Score(C) | Positive | 42(20.4%) | 148(71.8%) | 190(92.2%) 16(7.8%) | 0.046 | |
Negative | 0(0%) | 16(7.8%) | ||||
SP84 | Score(A) | Positive | 25(12.1%) | 87(42.2%) | 112(54.3%) 94(45.7%) | 0.491 |
Negative | 17(8.3%) | 77(37.4%) | ||||
Score(B) | Positive | 37(18%) | 123(59.7%) | 160(77.7%) 46(22.3%) | 0.095 | |
Negative | 5(2.4%) | 41(19.9%) | ||||
Score(C) | Positive | 42(20.4%) | 139(67.5%) | 181(87.9%) 25(12.1%) | 0.003 | |
Negative | 0(0%) | 25(12.1%) | ||||
| Â | Total | 42(20.4%) | 164(79.6%) | Â | ||