Table 1 Characteristics of the studies on the relationship between hyperhomocysyeinemia and risk of diabetic retinopathy
Source | Country | No. of case/control | DM Type | Blood | Exposure definition | Study quality†| Matching/comparable* |
|---|---|---|---|---|---|---|---|
Golbahar et al. 2008 [17] | Bahrain | 124/130 | 2 | Plasma | F: Hcy > 15 μmol/l; M: Hcy > 12 μmol/l | 8 | 1, 2, 3, 4, 7, 12, 13 |
Vaccaro et al , 1997 [8] | Japan | 11/14 | 1 | Plasma | ≥10 μmol/ | 6 | 1, 2, 6, 8, 9, 13 |
Hofmann et al., 1998 [18] | France | 26/49 | 1 | Plasma | Preload > 15.8 μmol/l or Postload > 31.1 μmol/l | 8 | 1, 2, 3, 4, 6, 7, 9 |
Hoogeveen et al., 2000 [5] | Netherlands | 534/91 | 2 | serum | >16 μmol/l | 7 | 1, 2, 7, 8, 9 |
Buysschaert et al., 2000 [19] | Belgium | 38/84 | 1 | Plasma | >15 μmol/l | 7 | 1, 2, 3, 5, 6, 10, 11, 12 |
Agullo-Ortuno et al., 2002 [3] | Spain | 18/71 | 1, 2 | Plasma | F >13.9 μmol/l, M >15.6 μmol/l | 5 | 9, 10, 11, 12 |
Goldstein et al., 2004 [4] | Israel | 84/251 | NA | Plasma | >15 μmol/l | 7 | 1, 6, 14 |
de Luis et al., 2005 [20] | Spain | 22/133 | 2 | Plasma | > 15 μmol/l | 6 | 1, 6, 7, 8, 9 |
Satyanarayana et al., 2011 [21] | US | 141/159 | 2 | Plasma | > 12 μmol/l | 7 | 1, 5, 9, 11 |