Association between cyclin D1 G870A polymorphism and cervical cancer risk: a cumulative meta-analysis involving 2,864 patients and 3,898 controls

Table 2 Summary ORs and 95% CI of CCND1 G870A polymorphisms and cervical cancer risk

		A vs. G				GA vs. GG				AA vs. GG				GA + AA vs. GG				AA vs. GG + GA
	N*	OR	95% CI	P	I²(%)^a	OR	95% CI	P	I²(%)^a	OR	95% CI	P	I²(%)^a	OR	95% CI	P	I²(%)^a	OR	95% CI	P	I²(%)^a
Total	10	1.02	0.88-1.19	0.76	74.5	0.98	0.77-1.26	0.90	69.1	1.03	0.75-1.41	0.85	75.9	1.00	0.78-1.28	0.99	72.3	1.06	0.85-1.32	0.62	70.1
HWE	8	1.01	0.86-1.18	0.92	71.9	1.08	0.85-1.39	0.52	62.2	1.00	0.72-1.39	0.99	73.1	1.06	0.82-1.36	0.66	68.7	0.97	0.79-1.20	0.79	59.8
Ethnicity
Caucasian	5	0.99	0.79-1.25	0.95	78.1	0.84	0.52-1.35	0.47	82.8	0.92	0.56-1.52	0.75	79.8	0.87	0.54-1.39	0.55	84.5	1.13	0.97-1.30	0.11	1.3
Asian	5	1.05	0.84-1.33	0.65	76.1	1.11	0.88-1.40	0.38	25.6	1.13	0.70-1.83	0.61	77.1	1.10	0.86-1.41	0.44	40.4	1.06	0.68-1.65	0.79	83.9
Design
Healthy base	4	0.98	0.71-1.36	0.91	76.8	0.88	0.47-1.64	0.70	78.1	0.90	0.45-1.78	0.76	77.5	0.89	0.47-1.67	0.71	81.3	1.02	0.79-1.31	0.91	6.7
Hospital base	4	1.11	0.87-1.40	0.40	71.7	0.99	0.60-1.63	0.96	79.4	1.24	0.75-2.07	0.40	74.5	1.06	0.68-1.66	0.80	76.6	1.25	0.82-1.89	0.30	77.1
Population base	2	0.94	0.64-1.39	0.76	91.0	1.08	0.91-1.28	0.38	0.0	0.87	0.39-1.95	0.73	91.2	1.00	0.70-1.44	0.99	72.7	0.85	0.42-1.70	0.64	92.0
Genotyping type
PCR-RFLP	8	1.00	0.82-1.23	0.97	78.3	0.94	0.67-1.33	0.73	75.3	0.98	0.64-1.51	0.93	79.6	0.96	0.68-1.34	0.79	77.3	1.04	0.77-1.40	0.80	74.9
Other	2	1.12	1.01-1.25	0.03	0.0	1.11	0.92-1.33	0.27	0.0	1.25	1.02-1.54	0.03	0.0	1.16	0.97-1.37	0.10	0.0	1.17	0.99-1.39	0.06	0.0

^*Numbers of comparisons ^aTest for heterogeneity. The significance of the bold values are all 0.03.

ISSN: 1746-1596