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Figure 3 | Diagnostic Pathology

Figure 3

From: Primary spleen extranodal NK/T cell lymphoma, nasal type, with bone marrow involvement and CD30 positive expression: a case report and literature review

Figure 3

Microscopic features of the spleen tumor and the bone marrow with immunohistochemical and in situ hybridization staining. (A) The structure of spleen white and red pulp was destroyed by the diffusely infiltrating neoplastic cells (HE × 100), (B) The size of the neoplastic cells were from medium to large with irregular pleomorphic hyperchromatin nuclei and conspicuous nucleoli. Giant tumor cells and apoptotic bodies were easily observed (HE × 200); (C) A splenic artery was infiltrated and destroyed by the lymphomatous cells (HE × 40); Tumor cells were postitive for CD2(D), CD3ε (E), CD56 (F), CD4 (G), CD8 (H), and CD30 (I) (Envision × 100); (J) Tumor cells were positive for EBERs by in situ hybridization; (K) Bone marrow biopsy showed scattered medium-sized tumor cells(arrow) (HE × 100); (L) Tumor cells of bone marrow were positive for CD56 (Envision × 100).

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Diagnostic Pathology

ISSN: 1746-1596

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