Table 1 Pathological characteristics
From: Automated quantification of Ki-67 proliferative index of excised neuroendocrine tumors of the lung
| Â | All tumors | Typical | Atypical | Large cell |
|---|---|---|---|---|
Mitotic count ( # /10 HPF) ‡ | 10.4 ± 1.5 | 0.1 ± 0.2 | 3.4 ± 2.1 | 56.1 ± 17.0 |
Range | 0-79 | 0-1 | 2-8 | 25-73 |
Ki-67 index ± SD (%) ‡ | 17.0 ± 29.4 | 2.3 ± 1.8 | 16.8 ± 7.7 | 81.3 ± 9.9 |
Range (%) | 0-91.9 | 0 - 6.7 | 9.9 - 25.7 | 63.2 - 91.9 |
Presence of necrosis # | Â | Â | Â | Â |
Absent | 43 (78%) | 39 (0%) | 4 (57%) | 0 (0%) |
Present | 12 (22%) | 0 (100%) | 3 (43%) | 9 (100%) |
Presence of LVI | Â | Â | Â | Â |
Absent | 43 (78%) | 33 (85%) | 5 (71%) | 5 (56%) |
Present | 12 (22%) | 6 (15%) | 2 (29%) | 4 (44%) |
Presence of perineural invasion | Â | Â | Â | Â |
Absent | 48 (87%) | 36 (92%) | 7 (100%) | 5 (56%) |
Present | 7 (13%) | 3 (8%) | 0 (0%) | 4 (44%) |
Spindle histology | Â | Â | Â | Â |
Absent | 48 (87%) | 32 (82%) | 5 (71%) | 9 (100%) |
Present | 7 (13%) | 7 (18%) | 2 (29%) | 0 (0%) |
Osseous metaplasia | Â | Â | Â | Â |
Absent | 49 (89%) | 34 (87%) | 6 (86%) | 9 (100%) |
Present | 6 (11%) | 5 (13%) | 1 (14%) | 0 (0%) |
Original pathological diagnosis | Â | Â | Â | Â |
Typical carcinoid | 40 | 36 | 4 | 0 |
Atypical carcinoid | 8 | 3 | 3 | 2 |
Large cell neuroendocrine | 4 | 0 | 0 | 4 |
Small cell carcinoma | 2 | 0 | 0 | 2 |
Poorly differentiated NSCLC | 1 | 0 | 0 | 1 |