Figure 2

Expressions of p16^INK4a, CRX and Ki67 in a representative RB case from FWR group (100×). a. HE staining showed FWR. b. p16^INK4a was moderately positive in FWR, but negative in the residual retina adjacent to the tumor. c. CRX expression was strongly positive in FWR, similar to the photoreceptors in the residual retina. d. Ki67 expression was similar to p16^INK4a, with a few of positive cells scattered in FWR. When comparing b and c, a complementary expression pattern between p16^INK4a and CRX is seen (black arrow). All inserts, 200x.