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Figure 3 | Diagnostic Pathology

Figure 3

From: p16INK4a expression in retinoblastoma: a marker of differentiation grade

Figure 3

Expressions of p16INK4a, CRX and Ki67 in different histological phenotypes of one RB case from HWR group (100×). a. HE staining showed 3 histological phenotypes of RB, including RC (in black frame), HWR (in red frame) and UD (in green frame). The yellow frame highlighted fleurette structures in RC region with higher magnification (200x). b. The level of p16INK4a progressively increased from the region RC to HWR, then to UD. c. CRX was strongly positive in both RC and HWR region, but weakly to moderately positive in UD. d. The number of Ki67 positive cells scattered was increased from region RC, HWR to UD.

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