Figure 4

Expressions of p16INK4a, CRX and Ki67 in a representative RB case from UD group (40×). a. HE staining showed the tumor predominantly consisted of UD cells with scanty cytoplasm and large nucleus forming pseudorosettes. b. p16INK4a was strongly positive in both cytoplasm and nucleus of most of tumor cells. c. CRX expression was weakly to moderately positive in these tumor cells. d. Most of UD cells were positive for Ki67, similar to p16INK4a. All inserts, 200x.