Figure 4

COX IV staining of the glomeruli and tubules. A: In the glomeruli of a normal control, the podocytes almost equally express COX IV. B. In the tubules of a normal control, the tubular cells at the same luminal level almost equally express COX IV. C. In the glomeruli of LBW 1, only one podocyte (arrow) expresses more COX IV than the other podocytes. D. In the tubules of LBW 1, unbalanced strong staining for COX IV is detected (arrows). Only a part of tubular cells express extremely intense COX IV compared with other tubular cells at the same luminal level. E: In the glomeruli of LBW 4, only one podocyte (arrow) expresses more COX IV than the other podocytes. F. In the tubules of LBW 4, staining for COX IV in a part of tubular lumens exhibits a mosaic pattern. The GSECs should express intense COX IV staining (arrows). G: In the glomeruli of Mt 1, a portion of podocytes (arrows) express more COX IV than the other podocytes. H: In the tubules of Mt 1, a portion of tubular cells are intensely stained (arrows) compared with the other cells in the same lumen. These cells should coincide with GSECs002E.