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Table 1 Summary of patients

From: Pathological similarities between low birth weight-related nephropathy and nephropathy associated with mitochondrial cytopathy

Case

Age

Sex

BMI1

Birth weight (g)

BP2(mmHg)

eGFR3(ml/min/1.73m2)

Urinary protein4(g/gCr)

Serum lactate5(mg/dl)

Long axis of kidney6(mm)

Number of total glomeruli

Global sclerosis7(%)

Segmental sclerosis8(%)

Glomerular hypertrophy9

Foot process effacement

mtDNA mutation10

LBW1

21

M

22.0

978

120/65

98

0.34

15.2

880

24

8.3

16.7

+

+

none

LBW2

20

M

21.0

1900

126/82

46

0.56

n.d.

848

4

0

25

+

+

none

LBW3

36

M

31.2

1400

125/75

74

1.35

n.d.

1208

14

42.9

7.1

+

+

none

LBW4

41

M

24.5

2465

121/70

63

0.83

15.8

988

20

15

10

+

+

none

Mt1

34

F

17.6

2720

115/63

48

0.29

9.1

936

11

45.5

0

-

+

3243 A>G

Mt2

28

F

17.5

3630

96/63

118

1.39

n.d.

953

16

0

0

-

+

3243 A>G

  1. 1BMI, body max index at the time of kidney biopsy.
  2. 2BP, blood pressure: BP at the time of kidney biopsy is expressed as systolic/diastolic.
  3. 3eGFR, estimated glomerular filtration: eGFR is calculated by Japanese GFR equation [12] from serum creatinine value, age, and sex at the kidney biopsy.
  4. 4The data of urinary protein is based on a urinalysis on the day of the kidney biopsy.
  5. 5Serum lactate is measured by an enzymatic assay (normal range: 3-17mg/dl). We did not measure the lactate values in three of six patients (expressed as n.d.).
  6. 6The long axis of the left kidney was measured by an echogram just before the kidney biopsy.
  7. 7The rate of the number of globally sclerosed glomeruli/total glomeruli in the observed section is expressed.
  8. 8 The rate of the number of segmentally sclerosed glomeruli/remnant glomeruli (total glomerular number minus GS glomeruli) is expressed.
  9. 9The existence of glomerular hypertrophy is defined when the diameter of capillary area is over 250 m [13].
  10. 10mtDNA mutation was surveyed in blood, urine, and kidney specimens by the PCR-Luminex method [11] except Mit2 patient, who was already diagnosed by a gene analysis in the other hospital.