Skip to main content

Table 2 Summary of the findings of nephropathy in the mitochondrial cytopathy and LBW-related nephropathy patients

From: Pathological similarities between low birth weight-related nephropathy and nephropathy associated with mitochondrial cytopathy

 

Normal

Mitochondrial cytopathy

LBW-related nephropathy

mtDNA mutation

No

Yes

No

FSGS lesion

No

Yes1

Yes

Glomerular hypertrophy

No

Yes or No

Yes

Foot process effacement

No

Yes

Yes

Increased mitochondria in podocyte

No

Yes

No

GSECs in tubules

No

Yes

Yes

COX IV expression in glomeruli

uniform

mosaic pattern

weak (but intense in a few podocytes)

COX IV expression in tubules

uniform

partially mosaic pattern

partially mosaic pattern

  1. 1Although the two patients with mitochondrial cytopathy had no FSGS lesions in the glomeruli, the presence of FSGS lesions is a characteristic glomerular change in mitochondrial cytopathy patients, as reported in many previous reports.