| Normal | Mitochondrial cytopathy | LBW-related nephropathy |
---|---|---|---|
mtDNA mutation | No | Yes | No |
FSGS lesion | No | Yes1 | Yes |
Glomerular hypertrophy | No | Yes or No | Yes |
Foot process effacement | No | Yes | Yes |
Increased mitochondria in podocyte | No | Yes | No |
GSECs in tubules | No | Yes | Yes |
COX IV expression in glomeruli | uniform | mosaic pattern | weak (but intense in a few podocytes) |
COX IV expression in tubules | uniform | partially mosaic pattern | partially mosaic pattern |