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Table 1 Characteristics of the studies included in the meta-analysis of ER-β gene polymorphisms and endometriosis

From: Associations between estrogen receptor-beta polymorphisms and endometriosis risk: a meta-analysis

Study Year Country Ethnicity Age, years, mean ± SD Sample size No. of infertility cases Source of controls Cases (Genotype) Controls Genotype) P HWE b
Cases Controls Cases Controls G/G G/A A/A G/G G/A A/A
rs4986938                 
Wang [16] 2004 Japan Asia NA NA 127 180 NA HB 104 22 1 130 49 1 0.26
Huang [21] 2005 China Asia 35.0 ± 10.0 34.0 ± 10.0 110 115 NA PB 78 27 5 82 29 4 0.48
Lee [18] 2007 Korea Asia 33.8 ± 6.7 41.6 ± 10.7 239 287 NA HB 179 60 0 208 75 4 0.34
Bianco [19] 2009 Brazil Mixed 34.1 ± 4.2 39.8 ± 4.5 108 210 108 HB 55 51 2 156 51 3 0.61
Zulli [20] 2010 Brazil Mixed 33.7 ± 4.0 39.8 ± 4.5 136 209 136 HB 82 52 2 162 44 3 0.99
Gu [17] 2012 China Asia 45.0 ± 6.0 40.0 ± 19.0 58 107 NA HB 47 11 0 80 27 0 0.14
Christofolini [22] 2011 Brazil Mixed 35.2 ± 3.9 34.4 ± 4.7 201 206 201 HB 123 76 2 145 58 3 0.30
Wu [23] 2013 China Asia 30.9 ± 6.3 29.1 ± 4.3 121 171 121 NA 97 24a NA 140 31a NA >0.05
rs1256049                 
Wang [16] 2004 Japan Asia NA NA 131 182 NA HB 71 56 4 98 73 11 0.59
Huang [21] 2005 China Asia 35.0 ± 10.0 34.0 ± 10.0 110 115 NA PB 17 55 38 30 61 24 0.49
Silva [24] 2011 Brazil Mixed 32.5c 37.4c 54 46 27 NA 22 32 0 43 3 0 0.82
Gu [17] 2012 China Asia 45.0 ± 6.0 40.0 ± 19.0 58 107 NA HB 27 19 12 50 45 12 0.70
  1. HB, hospital-based; PB, population-based; NA, not available; No., number.
  2. aGA + AA; bp value for Hardy-Weinberg equilibrium in controls; cMean age, years.