Associations between estrogen receptor-beta polymorphisms and endometriosis risk: a meta-analysis

Diagnostic Pathology

Table 1 Characteristics of the studies included in the meta-analysis of ER-β gene polymorphisms and endometriosis

Study	Year	Country	Ethnicity	Age, years, mean ± SD		Sample size		No. of infertility cases	Source of controls	Cases (Genotype)			Controls Genotype)			P _HWE ^b
Study	Year	Country	Ethnicity	Cases	Controls	Cases	Controls	No. of infertility cases	Source of controls	G/G	G/A	A/A	G/G	G/A	A/A	P _HWE ^b
rs4986938
Wang [16]	2004	Japan	Asia	NA	NA	127	180	NA	HB	104	22	1	130	49	1	0.26
Huang [21]	2005	China	Asia	35.0 ± 10.0	34.0 ± 10.0	110	115	NA	PB	78	27	5	82	29	4	0.48
Lee [18]	2007	Korea	Asia	33.8 ± 6.7	41.6 ± 10.7	239	287	NA	HB	179	60	0	208	75	4	0.34
Bianco [19]	2009	Brazil	Mixed	34.1 ± 4.2	39.8 ± 4.5	108	210	108	HB	55	51	2	156	51	3	0.61
Zulli [20]	2010	Brazil	Mixed	33.7 ± 4.0	39.8 ± 4.5	136	209	136	HB	82	52	2	162	44	3	0.99
Gu [17]	2012	China	Asia	45.0 ± 6.0	40.0 ± 19.0	58	107	NA	HB	47	11	0	80	27	0	0.14
Christofolini [22]	2011	Brazil	Mixed	35.2 ± 3.9	34.4 ± 4.7	201	206	201	HB	123	76	2	145	58	3	0.30
Wu [23]	2013	China	Asia	30.9 ± 6.3	29.1 ± 4.3	121	171	121	NA	97	24^a	NA	140	31^a	NA	>0.05
rs1256049
Wang [16]	2004	Japan	Asia	NA	NA	131	182	NA	HB	71	56	4	98	73	11	0.59
Huang [21]	2005	China	Asia	35.0 ± 10.0	34.0 ± 10.0	110	115	NA	PB	17	55	38	30	61	24	0.49
Silva [24]	2011	Brazil	Mixed	32.5^c	37.4^c	54	46	27	NA	22	32	0	43	3	0	0.82
Gu [17]	2012	China	Asia	45.0 ± 6.0	40.0 ± 19.0	58	107	NA	HB	27	19	12	50	45	12	0.70

HB, hospital-based; PB, population-based; NA, not available; No., number.
^aGA + AA; ^bp value for Hardy-Weinberg equilibrium in controls; ^cMean age, years.

ISSN: 1746-1596