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Table 2 Summary ORs and 95% CIs of the association between ER-β rs4986938 polymorphism and endometriosis

From: Associations between estrogen receptor-beta polymorphisms and endometriosis risk: a meta-analysis

Comparison No. of studies A vs. Gb AA vs. GGa,b GA vs. GGb AA + GA vs. GG AA vs. GA + GGa,b
OR (95% CI) P H OR (95% CI) P H OR (95% CI) P H OR (95% CI) P H OR (95% CI) P H
Overall 8 1.16 (0.82-1.64)R <0.001 0.95 (0.46-1.97)F 0.735 1.24 (0.80-1.91)R <0.001 1.21 (0.83-1.77)R <0.001 0.86 (0.41-1.77)F 0.790
ethnicity            
Asia 5 0.82 (0.65-1.04)F 0.552 0.75 (0.27-2.07)F 0.335 0.81 (0.62-1.05)F 0.456 0.85 (0.67-1.08)F 0.496 0.91 (0.26-3.13)F 0.331
Mixed 3 1.72 (1.37-2.17) c ,F 0.204 1.23 (0.43-3.49)F 0.795 2.08 (1.59-2.71) c ,F 0.159 2.03 (1.56-2.64) c ,F 0.148 0.97 (0.34-2.74)F 0.880
Sample size            
>300 5 1.26 (0.82-1.93)R <0.001 0.83 (0.34-1.99)F 0.611 1.41 (0.82-2.40)R <0.001 1.38 (0.81-2.34)R <0.001 0.71 (0.30-1.73)F 0.717
-300 3 0.94 (0.62-1.41)F 0.412 1.31 (0.34-5.07) - 0.86 (0.53-1.39)F 0.498 0.97 (0.67-1.39)F 0.624 1.32 (0.35-5.06) -
  1. OR, odds ratio; CI, confidence interval; No., number; PH, p value of Q-test for heterogeneity test; R, random-effect model; F, fixed-effect model.
  2. aThe study by Gu et al. was not included since they presented 0 frequency of AA genotype in cases and controls.
  3. bThe study by Wu et al. was not included since they just presented the data on GG and GA + AA genotypes in cases and controls.
  4. cStatistically significant results (in bold).