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Table 3 Summary ORs and 95% CIs of the association between ER-β rs1256049 polymorphism and endometriosis

From: Associations between estrogen receptor-beta polymorphisms and endometriosis risk: a meta-analysis

Comparison No. of studies A vs. G AA vs. GGa GA vs. GG AA + GA vs. GG AA vs. GA + GGa
OR (95% CI) P H OR (95% CI) P H OR (95% CI) P H OR (95% CI) P H OR (95% CI) P H
Overall 4 1.71 (0.92-3.16)R <0.001 1.50 (0.59-3.79)R 0.059 1.95 (0.75-5.09)R <0.001 2.11 (0.85-5.26)R <0.001 1.43 (0.66-3.08)R 0.089
Ethnicity            
Asia 3 1.23 (0.86-1.75)R 0.094 1.50 (0.59-3.79)R 0.059 1.09 (0.78-1.53)F 0.371 1.17 (0.85-1.61)F 0.229 1.43 (0.66-3.08)R 0.089
Mixed 1 12.49 (3.68-42.41) b - - - 20.85 (5.74-75.75) b - 20.85 (5.74-75.75) b - - -
Sample size            
>200 2 1.22 (0.69-2.16)R 0.03 1.26 (0.23-6.76)R 0.018 1.20 (0.82-1.76)F 0.341 1.22 (0.85-1.77)F 0.101 1.08 (0.28-4.27)R 0.035
-200 2 3.68 (0.36-37.65)R <0.001 1.85 (0.73-4.68) - 3.86 (0.15-102.43)R <0.001 4.35 (0.21-89.43)R <0.001 2.07 (0.86-4.95) -
  1. OR, odds ratio; CI, confidence interval; No., number; PH, P value of Q-test for heterogeneity test; R, random-effect model; F, fixed-effect model.
  2. aThe study by Silva et al. was not included since they presented 0 frequency of AA genotype in cases and controls.
  3. bStatistically significant results (in bold).