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Table 3 Summary ORs and 95% CIs of the association between ER-β rs1256049 polymorphism and endometriosis

From: Associations between estrogen receptor-beta polymorphisms and endometriosis risk: a meta-analysis

Comparison

No. of studies

A vs. G

AA vs. GGa

GA vs. GG

AA + GA vs. GG

AA vs. GA + GGa

OR (95% CI)

P H

OR (95% CI)

P H

OR (95% CI)

P H

OR (95% CI)

P H

OR (95% CI)

P H

Overall

4

1.71 (0.92-3.16)R

<0.001

1.50 (0.59-3.79)R

0.059

1.95 (0.75-5.09)R

<0.001

2.11 (0.85-5.26)R

<0.001

1.43 (0.66-3.08)R

0.089

Ethnicity

           

Asia

3

1.23 (0.86-1.75)R

0.094

1.50 (0.59-3.79)R

0.059

1.09 (0.78-1.53)F

0.371

1.17 (0.85-1.61)F

0.229

1.43 (0.66-3.08)R

0.089

Mixed

1

12.49 (3.68-42.41) b

-

-

-

20.85 (5.74-75.75) b

-

20.85 (5.74-75.75) b

-

-

-

Sample size

           

>200

2

1.22 (0.69-2.16)R

0.03

1.26 (0.23-6.76)R

0.018

1.20 (0.82-1.76)F

0.341

1.22 (0.85-1.77)F

0.101

1.08 (0.28-4.27)R

0.035

-200

2

3.68 (0.36-37.65)R

<0.001

1.85 (0.73-4.68)

-

3.86 (0.15-102.43)R

<0.001

4.35 (0.21-89.43)R

<0.001

2.07 (0.86-4.95)

-

  1. OR, odds ratio; CI, confidence interval; No., number; PH, P value of Q-test for heterogeneity test; R, random-effect model; F, fixed-effect model.
  2. aThe study by Silva et al. was not included since they presented 0 frequency of AA genotype in cases and controls.
  3. bStatistically significant results (in bold).