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Table 2 Stratified analyses of the COMT gene polymorphism and lung cancer risk

From: Association between Catechol-O-methyltransferase rs4680 (G > A) polymorphism and lung cancer risk

Variable n AA vs. GG AG vs. GG AA/AG vs. GG AA vs. AG/GG
   OR (95% CI) p a p b OR (95% CI) p a p b OR (95% CI) p a p b OR (95% CI) p a p b
Total 6 1.088 (0.677-1.749) 0.729 0.001 1.107 (0.962-1.275) 0.157 0.407 1.085 (0.867-1.357) 0.477 0.03 1.037 (0.686-1.568) 0.863 0.002
Ethnicity              
Asian 2 0.823 (0.351-1.930) 0.654 0.054 0.991 (0.634-1.549) 0.968 0.055 0.949 (0.566-1.592) 0.842 0.02 0.848 (0.438-1.642) 0.626 0.121
Caucasian 3 1.480 (0.627-3.491) 0.371 0.001 0.993 (0.797-1.238) 0.227 0.544 1.210 (0.845-1.732) 0.299 0.049 1.350 (0.642-2.839) 0.429 0.001
Control source              
Hospital-based 3 0.836 (0.531-1.315) 0.438 0.112 1.061 (0.892-1.262) 0.505 0.136 0.946 (0.687-1.304) 0.735 0.047 0.854 (0.612-1.192) 0.354 0.236
Population-based 3 1.560 (0.562-4.336) 0.393 0.001 1.204 (0.945-1.534) 0.134 0.816 1.277 (0.929-1.755) 0.132 0.153 1.434 (0.519-3.966) 0.487 0.001
Smoking status              
Never-smokers 2 0.846 (0.330-2.169) 0.728 0.043 1.064 (0.574-1.972) 0.844 0.012 1.016 (0.518-1.992) 0.963 0.004 0.842 (0.427-1.658) 0.618 0.13
Ever-smokers 2 2.326 (0.503-10.756) 0.28 0.014 0.994 (0.590-1.677) 0.983 0.096 1.174 (0.548-2.517) 0.680 0.010 2.394 (0.619-9.262) 0.206 0.028
  1. athe pooled p value; bp value for heterogeneity test.