Table 2 Stratified analyses of the COMT gene polymorphism and lung cancer risk
From: Association between Catechol-O-methyltransferase rs4680 (G > A) polymorphism and lung cancer risk
Variable | n | AA vs. GG | AG vs. GG | AA/AG vs. GG | AA vs. AG/GG | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | OR (95% CI) | p a | p b | OR (95% CI) | p a | p b | OR (95% CI) | p a | p b | OR (95% CI) | p a | p b |
Total | 6 | 1.088 (0.677-1.749) | 0.729 | 0.001 | 1.107 (0.962-1.275) | 0.157 | 0.407 | 1.085 (0.867-1.357) | 0.477 | 0.03 | 1.037 (0.686-1.568) | 0.863 | 0.002 |
Ethnicity | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Asian | 2 | 0.823 (0.351-1.930) | 0.654 | 0.054 | 0.991 (0.634-1.549) | 0.968 | 0.055 | 0.949 (0.566-1.592) | 0.842 | 0.02 | 0.848 (0.438-1.642) | 0.626 | 0.121 |
Caucasian | 3 | 1.480 (0.627-3.491) | 0.371 | 0.001 | 0.993 (0.797-1.238) | 0.227 | 0.544 | 1.210 (0.845-1.732) | 0.299 | 0.049 | 1.350 (0.642-2.839) | 0.429 | 0.001 |
Control source | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Hospital-based | 3 | 0.836 (0.531-1.315) | 0.438 | 0.112 | 1.061 (0.892-1.262) | 0.505 | 0.136 | 0.946 (0.687-1.304) | 0.735 | 0.047 | 0.854 (0.612-1.192) | 0.354 | 0.236 |
Population-based | 3 | 1.560 (0.562-4.336) | 0.393 | 0.001 | 1.204 (0.945-1.534) | 0.134 | 0.816 | 1.277 (0.929-1.755) | 0.132 | 0.153 | 1.434 (0.519-3.966) | 0.487 | 0.001 |
Smoking status | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Never-smokers | 2 | 0.846 (0.330-2.169) | 0.728 | 0.043 | 1.064 (0.574-1.972) | 0.844 | 0.012 | 1.016 (0.518-1.992) | 0.963 | 0.004 | 0.842 (0.427-1.658) | 0.618 | 0.13 |
Ever-smokers | 2 | 2.326 (0.503-10.756) | 0.28 | 0.014 | 0.994 (0.590-1.677) | 0.983 | 0.096 | 1.174 (0.548-2.517) | 0.680 | 0.010 | 2.394 (0.619-9.262) | 0.206 | 0.028 |