Table 3 The association of TNF-α −308G > A polymorphism with hepatocellular carcinoma risk
TNF-α −308 G > A polymorphism | HCC patients | Controls | OR (95% CI)1 | P value |
|---|---|---|---|---|
General genotype | ||||
GG | 611 | 733 | 1.00 (Reference) | |
AG | 98 | 25 | 2.12 (1.25–3.46) | 0.02 |
AA | 44 | 2 | 5.12 (2.31–7.82) | 0.003 |
Dominant genotype | ||||
GG | 611 | 733 | 1.00 (Reference) | |
AG + AA | 142 | 27 | 5.59 (2.41–8.02) | <0.001 |
Recessive genotype | ||||
AG + GG | 709 | 758 | 1.00 (Reference) | |
AA | 44 | 2 | 1.98 (0.95–3.27) | 0.06 |
Allele frequency | ||||
G | 1,320 | 1,491 | 1.00 (Reference) | 0.006 |
A | 186 | 29 | 4.18 (1.76–6.97) |