Table 1 Brief summary of cases reported in the literature of scrotal IgG4 related pseudotumor
From: IgG4-related disease of the paratestis in a patient with Wells syndrome: a case report
No. | Reference | Era | Age | Presentation | Diagnosis and multiorgan disease | Treatment | Serum IgG4 value (mg/dL) | Histology |
|---|---|---|---|---|---|---|---|---|
1 | Bösmüller et al. [2] | 2011 | 23 | Bilateral Palpable paratesticular multiple indolent floating masses on both sides | Paratesticular fibrous pseudotumor | Surgical excision of nodules | Not described | Plasma cell infiltration, IgG4/IgG ratio 44% |
2 | Bösmüller et al. [2] | 2011 | 25 | Right swelling of the right testis with pain | Paratesticular inflammatory pseudotumor | Semicastration. | Not described | Dense myofibroblastic proliferation with sparse mitoses, IgG4/IgG ratio 48% |
3 | Bösmüller et al. [2] | 2011 | 52 | Right palpable paratesticular nodules | Paratesticular fibrous pseudotumor | Surgical excision of nodules | Not described | Plasma cell infiltration, IgG4/IgG ratio 46% |
4 | Hart et al. [3] | 2012 | 73 | Painless right scrotal mass | Paratesticular pseudotumor, Autoimmune pancreatitis, Retroperitoneal fibrosis | Right inguinal radical orchiectomy | 391 | Lymphoplasmacytic infiltration, storiform pattern of fibrosis, IgG4/IgG ratio 60% |
5 | Migita et al. [4] | 2012 | 74 | Left paratesticular mass | Paratesticular pseudotumor, Submandibular gland inflammation, prostatitis | Left semicastration | 505 | Fibrosis with lymphocytic and plasmacytic infiltrations, IgG4/IgG ratio 85% |
6 | Dickmann et al. [5] | 2013 | 19 | Right painless intrascrotal mass | Spermatic cord inflammatory pseudotumor | Local excision | Not determined | Partially storiform, spindle-like cells and lymphofollicular infiltration, IgG4/IgG ratio 40% |
7 | Dickmann et al. [5] | 2013 | 28 | Right painless intrascrotal mass | Spermatic cord inflammatory pseudotumor | Local excision | Not determined | As above |
8 | de Buy Wenniger et al. [6] | 2013 | 64 | Bilateral scrotal pain | Testicular pseudotumor, Autoimmune pancreatitis, Retroperitoneal fibrosis | Bilateral orchidectomy | Not described | Plasma cell-rich infiltrate and myofibroblastic spindle cell proliferation around the seminiferous tubules, IgG4/IgG ratio 50% in right testis and 80% in left testis |
9 | Our case | 2014 | 33 | Left palpable scrotal mass | Paratesticular pseudotumor, Lung lesion | Radical orchidectomy | 31.8 | Spindle epithelial and polygonal cell proliferation with intense fibrous, plasmacyte, lymphocyte and eosinophil infiltration, IgG4/IgG ratio 50% |