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Table 3 Response to treatment according to TTF1-expression (n = 178)

From: Value of thyroid transcription factor (TTF)-1 for diagnosis and prognosis of patients with locally advanced or metastatic small cell lung cancer

  TTF1 + 150 (84.3%) TTF1 –n = 28 (15.7%) p-value
CR 8 (5.3%) 4 (14.3%)  
PR 105 (70.0%) 16 (57.1%)  
SD 22 (14.7%) 0  
PD 15 (10.0%) 8 (28.6%) 0.003
RR 75.3% 71.4% 0.642
DCR (overall) 135 (90.0%) 20 (71.4%) 0.013
DCR stage III 56/58 (96.6%) 10/10 (100%) 0.726
DCR stage IV 79/92 (85.9%) 10/18 (55.6%) 0.006
  1. Overall response rate (RR) is defined as the proportion of patients having at least a partial response according to RECIST1.0. Disease control rate (DCR) is defined as all patients with at least a stable disease according to RECIST1.0. (CR = complete response; PR = partial response; SD = stable disease; PD = progressive disease).