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Figure 3 | Diagnostic Pathology

Figure 3

From: Accumulation of invariant NKT cells with increased IFN-γ production in persistent high-risk HPV-infected high-grade cervical intraepithelial neoplasia

Figure 3

The proportion of iNKT cells in total CD3+ T cells in HPV-positive cervical tissues is significantly increased, especially increased in ≥ CINII subgroup; and the proportion of iNKT cells to CD3+ T cells in ≥ CINII subgroup is significantly in the HPV-positive group, but in < CINII cervical tissues of the HPV-positive group is similar to that in the HPV-negative group. A, Flow cytometry plots of iNKT cells in CD3+ T cells in HPV-positive and HPV-negative cervical tissues, as detected by Vα24 and Vβ11 staining; B, The bar graph shows iNKT cells as percentages of CD3+ T cells isolated from HPV-positive and HPV-negative cervical tissues (*p = 0.017). C, Flow cytometry plots of iNKT cells in CD3+ T cells in the HPV-positive cervical tissues of ≥ CINII and < CINII subgroups, as detected by Vα24 and Vβ11 staining; D, The bar graph shows iNKT cells as percentages of CD3+ T cells isolated from HPV-positive cervical tissues of ≥ CINII and < CINII subgroups (*p = 0.001). E, Flow cytometry plots of iNKT cells in CD3+ T cells from the ≥ CINII subgroup of HPV-positive cervical tissues and HPV-negative cervical tissues, as detected by Vα24 and Vβ11 staining; F, The bar graph shows iNKT cells as percentages of CD3+ T cells isolated from ≥ CINII subgroup of HPV-positive cervical tissues and HPV-negative cervical tissues (p = 0.046).

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