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Figure 1 | Diagnostic Pathology

Figure 1

From: High microRNA-23a expression in laryngeal squamous cell carcinoma is associated with poor patient prognosis

Figure 1

miR-23a expression is associated with lymph node metastasis and survival rate in LSCC. (A) Relative miR-23a expression in 52 LSCC patients. The relative expression was calculated as the ratio of miR-23a in cancer tissue to that in paired adjacent tissue in each case. The digit on the X-axis shows the number of samples used in the study. (B) General miR-23a expression in LSCC. T and R are cancer and matched adjacent tissues, respectively. miR-23a was normalized by U6 RNA. Symbol *indicates P < 0.05. (C) miR-23a expression in LSCC with lymph node metastasis. T and R are cancer and matched adjacent tissues, respectively. miR-23a was normalized by U6 RNA. *indicates P < 0.05, n = 18. (D) miR-23a expression in cancer and paired tissues in different survival groups. T and R are cancer and matched adjacent tissues, respectively. miR-23a was normalized by U6 RNA. *indicates P < 0.05, n = 37 in survival less than 5-year group and n = 15 in survival more than 5-year group. (E) miR-23a expression in cancer tissues in different survival groups. miR-23a was normalized by U6 RNA. *indicates P < 0.05, n = 52. (F) Postoperative 5-year survival curves of LSCC patients correlated to miR-23a expression. Kaplan–Meier estimates of overall 5-year survival for the LSCC patients with low miR-23a expression (fold change ≤ 2) and high miR-23a expression (fold change >2), respectively. The P value was calculated using the Log-rank test between patients with low and high miR-23a expression.

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