Table 2 Enriched KEGG pathways in different contrastive groups
KEGG pathway | Count | P value | ||
|---|---|---|---|---|
HFF1_24 h vs HFF1 | Up-regulated gene | hsa04622: RIG-I-like receptor signaling pathway | 6 | 9.35E-05 |
hsa04620: Toll-like receptor signaling pathway | 5 | 0.0043 | ||
hsa04623: Cytosolic DNA-sensing pathway | 4 | 0.0057 | ||
HFF1_48 h vs HFF1 | Up-regulated gene | hsa04620: Toll-like receptor signaling pathway | 6 | 0.0209 |
hsa04622: RIG-I-like receptor signaling pathway | 5 | 0.0249 | ||
Down-regulated gene | hsa05410: Hypertrophic cardiomyopathy (HCM) | 4 | 0.0479 | |
HFF1_72 h vs HFF1 | Up-regulated gene | hsa00330: Arginine and proline metabolism | 6 | 0.0076 |
hsa00480: Glutathione metabolism | 5 | 0.0287 | ||
hsa00250: Alanine, aspartate and glutamate metabolism | 4 | 0.0349 | ||
Down-regulated gene | hsa04510: Focal adhesion | 13 | 4.57E-05 | |
hsa04810: Regulation of actin cytoskeleton | 10 | 0.0056 | ||
hsa05200: Pathways in cancer | 11 | 0.0272 | ||
ES vs HFF1 | Up-regulated gene | hsa05217: Basal cell carcinoma | 14 | 9.58E-06 |
hsa04310: Wnt signaling pathway | 22 | 1.28E-04 | ||
hsa05200: Pathways in cancer | 36 | 2.29E-04 | ||
hsa00330: Arginine and proline metabolism | 10 | 0.0029 | ||
Down-regulated gene | hsa04510: Focal adhesion | 40 | 8.73E-08 | |
hsa00520: Amino sugar and nucleotide sugar metabolism | 13 | 1.09E-04 | ||
hsa04512: ECM-receptor interaction | 18 | 2.52E-04 | ||
hsa04142: Lysosome | 20 | 0.0019 | ||
iPS vs HFF1 | Up-regulated gene | hsa04310: Wnt signaling pathway | 16 | 2.39E-04 |
hsa05217: Basal cell carcinoma | 8 | 0.0029 | ||
hsa00250: Alanine, aspartate and glutamate metabolism | 6 | 0.0041 | ||
hsa00260: Glycine, serine and threonine metabolism | 6 | 0.0041 | ||
Down-regulated gene | hsa04510: Focal adhesion | 56 | 1.46E-11 | |
hsa04512: ECM-receptor interaction | 27 | 3.06E-07 | ||
hsa00520: Amino sugar and nucleotide sugar metabolism | 16 | 2.84E-05 | ||
hsa04810: Regulation of actin cytoskeleton | 42 | 1.43E-04 |