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Table 1 A comparison of the clinical and histological features of KD with ALHE

From: Kimura disease accompanied with Nephrotic syndrome in a 45-year-old male

 

Kimura disease

Angiolymphoid hyperplasia with eosinophilia

clinical features

  

Sex

Female predominance (70%)

Male predominance (85%)

Age

Young adulthood

Young to middle age

Race

More common in Asians

Occurs in all races

Location

Head and neck

Head and neck

Presentation

Localized subcutaneous mass

Dermal papules or nodules

Number

Single or multiple

Usually multiple

Size

Average 3 cm

Average 1 cm

Lymph node involvement

Common

Rare

peripheral eosinophilia

Almost invariably present

Rare (20%)

Serum immunoglobulin E (IgE) level

Elevated

Normal

Renal involvement

Occasional (21%)

Rare

Recurrence rate

30%

15-40%

Histopathological features

  

Depth

Subcutaneous, muscle

Cutaneous, subcutaneous

Vascular proliferation

Some degree of vascular proliferation

Florid vascular proliferation

Lymphoid follicles

Always found

May be present

Eosinophils

Abundant

Sparse to abundant

Eosinophils abscesses

Present

Not seen

Endothelium

Flattened

Cuboidal to dome shaped:"Histiocytoid"

Fibrosis

Present

Absent