From: Kimura disease accompanied with Nephrotic syndrome in a 45-year-old male
Kimura disease | Angiolymphoid hyperplasia with eosinophilia | |
---|---|---|
clinical features | ||
Sex | Female predominance (70%) | Male predominance (85%) |
Age | Young adulthood | Young to middle age |
Race | More common in Asians | Occurs in all races |
Location | Head and neck | Head and neck |
Presentation | Localized subcutaneous mass | Dermal papules or nodules |
Number | Single or multiple | Usually multiple |
Size | Average 3 cm | Average 1 cm |
Lymph node involvement | Common | Rare |
peripheral eosinophilia | Almost invariably present | Rare (20%) |
Serum immunoglobulin E (IgE) level | Elevated | Normal |
Renal involvement | Occasional (21%) | Rare |
Recurrence rate | 30% | 15-40% |
Histopathological features | ||
Depth | Subcutaneous, muscle | Cutaneous, subcutaneous |
Vascular proliferation | Some degree of vascular proliferation | Florid vascular proliferation |
Lymphoid follicles | Always found | May be present |
Eosinophils | Abundant | Sparse to abundant |
Eosinophils abscesses | Present | Not seen |
Endothelium | Flattened | Cuboidal to dome shaped:"Histiocytoid" |
Fibrosis | Present | Absent |