Fig. 3

Histopathologic features. a Necrotic tissue (*, HE x 1000). b Silver staining revealed the necrotic tissue preserved the structure of the hepatic cell plate and involved the portal tract, suggesting that it is a result of necrosis of the hepatocytes (*, silver staining x 1000). c Fibrous tissue (†, HE x 1000). d Fibrous tissue (†, silver staining x 1000). e The outermost layer was the band of granuloma comprising macrophages of epithelioid feature cells, lymphocytes and plasma cells with some infiltration of eosinophils forming a distinct boundary between normal hepatic tissue and the necrotic region. Multinucleated giant cells were present but not prominent (‡, HE x 1000). f The outermost layer (‡, silver staining x 1000)