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Table 2 Ki-67 as a predictor of clinically significant outcomes

From: Comparison of digital image analysis and visual scoring of KI-67 in prostate cancer prognosis after prostatectomy

Outcome: Biochemical recurrence
  HR 95 % CI p-value
Univariate model    
Ki-67*,& 1.29 0.97-1.73 0.019
Multivariate model    
Ki-67*& 1.46 1.10-1.94 0.009
PSA (μg/L) 1.02 1.01-1.03 <0.001
Gleason Score& 1.09 0.94-1.26 0.25
pT3N + M+ 1.47 1.17-1.84 <0.001
Age (years) 0.96 0.93-0.99 0.02
Outcome: Death from prostate cancer
  HR 95 % CI p-value
Univariate model    
Ki-67& 1.19 1.01-1.41 0.040
Multivariate model    
Ki-67& 1.26 1.06-150 0.010
PSA (μg/L) 1.01 0.98-1.04 0.577
Gleason Score& 1.30 0.79-2.14 0.293
pT3N + M+ 3.49 1.19-10.23 0.022
Age (years) 0.97 0.86-1.08 0.554
  1. Ki-67*: The square root of Ki-67; PSA: Prostate-specific antigen; HR: Hazard ratio; CI: Confidence interval
  2. &Ki-67 was assessed as a continuous variable. Gleason score was dichotomized to <7 vs ≥ 7