Table 2 Main points of differential diagnosis
Diseases | Medical history | Morphology | Immunohistochemistry | FISH (SS18) | |||||
|---|---|---|---|---|---|---|---|---|---|
CK | S-100 | SMA | SOX10 | TLE1 | Calretinin | ||||
Primary cacdiac biphasic SS | No | biphasic | + | +/- | - | -/+ | + | - | Yes |
Metastatic carcinosarcoma | Yes | biphasic | + | - | +/- | - | - | - | No |
Metastatic myoepithelial carcinoma | Yes | biphasic | + | + | + | - | - | - | No |
Mesothelioma | No | biphasic | + | - | - | - | - | + | No |
MPNST with epithelial differentiation | No | biphasic | + | + | - | + | +/- | - | No |